Recombinant Human LILRA6/CD85b/ILT8 Protein, CF Summary
Gly24-Asn447, with a C-terminal 6-His tag
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
LILRA6, also known as ILT8 and CD85b, is a transmembrane molecule that belongs to the LILR family of immune regulatory proteins (1, 2). Among family members, LILRA6 is most closely related to LILRB3/CD85a/ILT5; these proteins share 94% amino acid (aa) sequence identity in their extracellular domains (ECD). Mature human LILRA6 consists of a 424 aa ECD with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 13 aa cytoplasmic domain (3). It contains a positively charged arginine residue in the transmembrane segment which may mediate association with the signaling protein Fc epsilon RI gamma. Alternative splicing generates a short isoform that is truncated near the middle of the ECD. LILRA6 is highly polymorphic, and its gene is found in variably copy numbers (4, 5). LILRA6 is primarily expressed on monocytes (4). R&D Systems in-house testing indicates that LILRA6 binds to Angiopoietin-like 7, consistent with the demonstrated functional interactions between other members of these protein families (6).
- Thomas, R. et al. (2010) Clin. Rev. Allergy Immunol. 38:159.
- Hirayasu, K. and H. Arase (2015) J. Hum. Genet. 60:703.
- Wende, H. et al. (2000) Immunogenetics 51:703.
- Bashirova, A.A. et al. (2014) Immunogenetics 66:1.
- Lopez-Alvarez, M.R. et al. (2014) Immunogenetics 66:73.
- Zheng, J. et al. (2012) Nature 485:656.
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