Recombinant Human LRIT2 Protein, CF

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R&D Systems Recombinant Proteins and Enzymes
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Recombinant Human LRIT2 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE with silver staining
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by the ability of the immobilized protein to support the adhesion of BCE C/D‑1b bovine corneal endothelial cells. The ED50 for this effect is 0.6-3 μg/mL.
Chinese Hamster Ovary cell line, CHO-derived human LRIT2 protein
Gln21-His462 (Leu220Phe) with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Predicted Molecular Mass
49 kDa
67-81 kDa, reducing conditions

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: LRIT2

Leucine-rich Repeat, Immunoglobulin-like domain and Transmembrane domain-containing protein 2 (LRIT2), also known as leucine-rich repeat protein 22 (LRRC22), is a 550 amino acid (aa) type I transmembrane protein. Its extracellular domain (ECD) contains one LRRNT, LRRCT, Ig-like, and Fibronectin type-III domain, and four leucine-rich repeats (LRRs). Within the ECD, human LRIT2 shares approximately 75% aa sequence identity with the mouse and rat orthologs. The LRR is a structural motif consisting of 20 to 30 aa repeated 2 to 45 times that forms a hydrophobic horseshoe shape with a parallel beta  sheet on the concave side and helical elements on the convex side (1-4). All LRRs are composed of a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif (1-4). LRR motifs mediate protein-protein interactions in a variety of proteins including tyrosine kinase receptors, hormone receptors, extracellular matrix-binding proteins, cell-adhesion molecules, and bacterial virulence factors (1, 3). Proteins containing LRRs play important roles in many biologically processes such as mammalian and neural development, cell polarization, gene expression, and apoptosis (2).

  1. Kobe, B. and J. Deisenhofer (1994) Trends Biochem. Sci. 19:415.
  2. Kobe, B. and A.V. Kajava (2001) Curr. Opin. Struct. Biol. 11:725.
  3. Enkhbayar, P. et al. (2004) Proteins 54:394.
  4. Bella, J. et al. (2008) Cell. Mol. Life Sci. 65:2307.
Long Name
Leucine-Rich Repeat, Immunoglobulin-Like And Transmembrane Domains 2
Entrez Gene IDs
340745 (Human); 239038 (Mouse)
Alternate Names
immunoglobulin-like domain and transmembrane domain-containing protein 2; leucine rich repeat containing 22; leucine-rich repeat, immunoglobulin-like and transmembrane domains 2; leucine-rich repeat-containing protein 22; LRIT2; LRRC22; PAL2


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