Recombinant Human LRRC24 His-tag Protein, CF

R&D Systems | Catalog # 10512-LR

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Key Product Details

  • R&D Systems CHO-derived Recombinant Human LRRC24 His-tag Protein (10512-LR)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

CHO

Accession Number

Q50LG9.2

Applications

Bioactivity
View all LRRC24 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human LRRC24 protein
Cys23-Ser365, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Cys23

Predicted Molecular Mass

38 kDa

SDS-PAGE

45-55 kDa, under reducing conditions

Activity

Bioassay data are not available.

Scientific Data Images for Recombinant Human LRRC24 His-tag Protein, CF

Recombinant Human LRRC24 His-tag Protein SDS-PAGE.

2 μg/lane of Recombinant Human LRRC24 His-tag (Catalog # 10512-LR) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 45-55 kDa.

Formulation, Preparation, and Storage

10512-LR
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: LRRC24

Leucine-rich repeat-containing protein 24 (LRRC24) is type I transmembrane protein found within the large LRR superfamily. The LRR family is known to have diverse functions, including roles in innate immunity and nervous system development (1). The extracellular domain (ECD) of LRRC24 contains several LRR repeats along with an Ig-like C2-type region. The mature ECD of human LRRC24 shares 86% and 80% amino acid sequence identity with mouse and rat LRRC24, respectively. LRRC24 has been shown to interact with Robo2, which is important for axon guidance and cell migration (2). LRRC24 has been suggested to be a novel negative regulator of the ErbB family and suppress ErbB-driven tumor cell proliferation and motility (3).

References

  1. Ng, A.C.Y. et al. (2011) PNAS 108:4631.
  2. Söllner, C. and Wright, G.J. (2009) Genome Biol. 10:R99.
  3. Andrews, A. et al. (2017) DOI:10.21767/2254-6081-C1-003.

Long Name

Leucine-rich Repeat Containing 24

Alternate Names

LRRC14OS

Entrez Gene IDs

441381 (Human); 378937 (Mouse); 362945 (Rat)

Gene Symbol

LRRC24

UniProt

Q50LG9.2

Additional LRRC24 Products

Product Documents for Recombinant Human LRRC24 His-tag Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human LRRC24 His-tag Protein, CF

For research use only

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