Recombinant Human LRRN2 His-tag, CF Summary
Ala19-Gly630, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
2 μg/lane of Recombinant Human LRRN2 His-tag was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 73-81 kDa.
Leucine-rich repeat neuronal protein 2 (LRRN2) is a type I transmembrane protein containing leucine-rich repeats (1). Mature human LRRN-2 consists of a 612 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 62 aa cytoplasmic domain. Within the ECD, human LRRN-2 shares 92% with mouse and rat LRRN-2. LRRN-2 is expressed in neuronal tissue postsynaptic membranes (1, 2). It is involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. LRRN-2 regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites (1, 2). LRRN-2 is up-regulated after NGF-induced differentiation and down-regulated after NGF depletion-induced apoptosis in mouse superior cervical ganglion cells (2).
- Lauren, J. et al. (2003) Genomics 81:411.
- Hamano, S. et al. (2004) Int. J. Oncol. 24:1457.
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