Recombinant Human Lymphotoxin beta R (LTbR) Fc Chimera, CF

Newer Version Available: 7538-LR
A New rh LT beta R is Available! It has ~2 fold better activity; Lower endotoxin specification; No his tag!
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Citations (5)
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Recombinant Human Lymphotoxin beta R (LTbR) Fc Chimera, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Mouse myeloma cell line, NS0-derived human Lymphotoxin beta R/TNFRSF3 protein
Human LT beta R
(Ser28-Met227) &
Accession # NP_002333
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Ser28 & No results obtained: Gln31 predicted
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
49.6 kDa (monomer)
70 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: Lymphotoxin beta R/TNFRSF3

Lymphotoxin beta receptor (LT beta R), previously called TNF RIII or TNF R‑related protein (TNF Rrp), is a type I transmembrane glycoprotein within the TNF receptor superfamily, designated TNFRSF3 (1‑3). Human LT beta R cDNA encodes 435 amino acids (aa) including a 30 aa signal peptide, a 197 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 187 aa cytoplasmic domain. The ECD contains four cysteine‑rich motifs characteristic of the TNF receptor superfamily (1, 2). Within the ECD, human LT beta R shares 67‑74% aa sequence identity with mouse, rat, canine, porcine, equine and bovine LT beta R. Soluble LT beta R can be formed by proteolytic cleavage of the ECD, and is an inhibitor of transmembrane LT beta R, as is recombinant LT beta R, which inhibits autoimmunity (3‑6). Potential human isoforms include a 416 aa form with an alternate N‑terminal signal sequence, and a 328 aa form that begins at aa 108 (7). LT beta R is expressed by visceral, lymphoid, and other stroma, epithelia and myeloid cells, but not lymphocytes (2, 4). LT beta R ligands include homotrimers of LIGHT (TNFSF14; also a ligand for HVEM) and the heterotrimeric lymphotoxin LT alpha 1/ beta 2 (3, 4, 6). Depending on the cell type and expression of TRAF3, activation of LT beta R has been shown to induce canonical (IKK/RelA; pro‑inflammatory) or alternative (NIK/RelB; lymphoid organogenic) NF kappa B activation (6, 8). LT beta R is expressed on mesenchymal stromal organizing cells that give rise to stroma of primary (thymus), secondary (tonsils, lymph nodes and Peyers patches) and tertiary (ectopic inflammatory) lymphoid structures (3‑5, 9‑11). Secondary immune tissues are absent in LT beta R‑deficient mice (3 ‑ 5). LT beta R engagement induces production of IL‑7, RANK, TRANCE/RANK L, VEGF‑C, adhesion molecules such as VCAM‑1, ICAM‑1 and MAdCAM, and chemokines such as CXCL13, CCL19 and CCL21 (3, 9 ‑ 11). LT beta R is expressed by hepatocytes, is up‑regulated in regeneration, hepatitis and hepatocellular carcinoma, and influences lipid metabolism and atherosclerosis (4, 6, 12). It regulates cell growth and can initiate inflammation‑related carcinogenesis (6, 12).

  1. Crowe, P.D. et al. (1994) Science 264:707.
  2. Force, W.R. et al. (1995) J. Immunol. 155:5280.
  3. McCarthy, D.D. (2006) Immunol. Res. 35:41.
  4. Tumanov, A.V. et al. (2007) Curr. Mol. Med. 7:567.
  5. Boehm, T. et al. (2003) J. Exp. Med. 198:757.
  6. Wolf, M.J. et al. (2010) Oncogene 29:5006.
  7. Entrez accession # BAH11468 and BAG53051.
  8. Bista, P. et al. (2010) J. Biol. Chem. 285:12971.
  9. van de Pavert, S.A. et al. (2010) Nat. Rev. Immunol. 10:664.
  10. Mouri, Y. et al. (2011) J. Immunol. 186:5047.
  11. Vondenhoff, M.F. et al. (2009) J. Immunol. 182:5439.
  12. Haybaeck, J. et al. (2009) Cancer Cell 16:295.
Long Name
Lymphotoxin beta Receptor
Entrez Gene IDs
4055 (Human); 17000 (Mouse); 297604 (Rat); 102135920 (Cynomolgus Monkey); 712550 (Rhesus Macaque)
Alternate Names
CD18; D12S370; ltbetar; LT-BETA-R; LTBR; lymphotoxin B receptor; Lymphotoxin beta R; lymphotoxin beta receptor (TNFR superfamily, member 3); Lymphotoxin-beta receptor; LymphotoxinbR; TNF RIII; TNF Rrp; TNFCRTNF-RIII; TNFR superfamily, member 3; TNFR2-RP; TNFR3; TNF-R-III; TNFR-RP; TNFRSF3; TNFRSF3TNFR-III; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; Tumor necrosis factor receptor type III

Citations for Recombinant Human Lymphotoxin beta R (LTbR) Fc Chimera, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3
    Authors: S Koh, J Kah, CYL Tham, N Yang, E Ceccarello, A Chia, M Chen, A Khakpoor, A Pavesi, AT Tan, M Dandri, A Bertoletti
    Gastroenterology, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. SM22? suppresses cytokine-induced inflammation and the transcription of NF-?B inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells
    Authors: X Dai, D Thiagaraja, J Fang, J Shen, NP Annam, Z Yang, H Jiang, D Ju, Y Xie, K Zhang, YY Tseng, Z Yang, AK Rishi, HJ Li, M Yang, L Li
    PLoS ONE, 2017;12(12):e0190191.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.
    Authors: Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S
    Biomaterials, 2010;31(12):3357-63.
    Species: N/A
    Sample Types: Virus
    Applications: Surface Plasmon Resonance
  4. The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells.
    Authors: Dhawan P, Su Y, Thu YM, Yu Y, Baugher P, Ellis DL, Sobolik-Delmaire T, Kelley M, Cheung TC, Ware CF, Richmond A
    J. Biol. Chem., 2008;283(22):15399-408.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis.
    Authors: Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A
    Arthritis Rheum., 2006;54(5):1451-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay


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