Recombinant Human LYPD8 Fc Chimera Protein, CF

  
  • Purity
    >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its binding ability in a functional ELISA. When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/mL, Recombinant Human Galectin‑3 (Catalog # 1154-GA) binds with a typical ED50 = 90-540 ng/mL.
  • Source
    Chinese Hamster Ovary cell line, CHO-derived
    Human LYPD8
    (Leu20-Asn215)
    Accession # Q6UX82
    IEGRMD Human IgG1
    (Pro100-Lys330)
    N-terminus C-terminus
  • N-terminal Sequence
    Analysis
    Leu20
  • Structure / Form
    Disulfide-linked homodimer
  • Predicted Molecular Mass
    48 kDa
  • SDS-PAGE
    85-100 kDa, reducing conditions
9087-C4
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/ml, Recombinant Human Galectin‑3 (Catalog # 1154-GA) binds with a typical ED50 of 90-540 ng/mL.
Background: LYPD8
Ly6/PLAUR domain containing 8 (LYPD8), is a GPI-linked protein with structural similarity to the urokinase-type plasminogen activator receptor (uPAR) (1). Mature human LYPD8 contains one uPAR/Ly6 domain and a Ser/Thr/Pro-rich (STP) region that may serve as a target for protease mediated shedding as has been shown for the related C4.4A/LYPD3 molecule (2, 3). Mature human LYPD8 shares 40% amino acid sequence identity with mouse and rat LYPD8.
  • References:
    1. Kong, H.K. and J.H. Park (2012) BMB Rep. 45:595.
    2. Hansen, L.V. et al. (2004) Biochem. J. 380:845.
    3. Esselens, C.W. et al. (2008) Biol. Chem. 389:1075.
  • Long Name:
    Ly6/PLAUR Domain-containing Protein 8
  • Entrez Gene IDs:
    646627 (Human); 70163 (Mouse); 691259 (Rat)
  • Alternate Names:
    LYPD8
Related Research Areas

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