>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/mL,
Human Galectin‑3 (Catalog # 1154-GA)
binds with a typical ED50 = 90-540 ng/mL.
Chinese Hamster Ovary cell line, CHO-derived
Human LYPD8 (Leu20-Asn215) Accession # Q6UX82
Human IgG1 (Pro100-Lys330)
N-terminal Sequence Analysis
Structure / Form
Predicted Molecular Mass
85-100 kDa, reducing conditions
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.
When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/ml, Recombinant Human Galectin‑3 (Catalog # 1154-GA) binds with a typical ED50 of 90-540 ng/mL.
Ly6/PLAUR domain containing 8 (LYPD8), is a GPI-linked protein with structural similarity to the urokinase-type plasminogen activator receptor (uPAR) (1). Mature human LYPD8 contains one uPAR/Ly6 domain and a Ser/Thr/Pro-rich (STP) region that may serve as a target for protease mediated shedding as has been shown for the related C4.4A/LYPD3 molecule (2, 3). Mature human LYPD8 shares 40% amino acid sequence identity with mouse and rat LYPD8.
Kong, H.K. and J.H. Park (2012) BMB Rep. 45:595.
Hansen, L.V. et al. (2004) Biochem. J. 380:845.
Esselens, C.W. et al. (2008) Biol. Chem. 389:1075.
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