Recombinant Human mGluR2 Protein, CF

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Recombinant Human mGluR2 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Mouse myeloma cell line, NS0-derived human mGluR2 protein
Gly20-Ser498, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Predicted Molecular Mass
54 kDa
60-75 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS and DTT.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: mGluR2

Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins and modulate glutamate neurotransmission in the central and peripheral nervous systems (1). Structurally, members from this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane domains, and a cytoplasmic carboxyl-terminal domain variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (3). Intracellularly, a short C-terminus interacts directly with a G-protein (2). The receptors are subdivided into three groups (I–III) based on sequence homology, signal transduction and pharmacological properties (1). The Group II receptors comprise mGLuR2 and mGLuR3, which share high sequence homology. mGLuR2 is a presynaptic receptor expressed on both neurons and glia, and its activation regulates cAMP accumulation (1). Mature human mGluR2 is 854 amino acids in length, including a 549 amino acid (aa) N-terminal ECD. Within N-terminal ECD, human mGluR2 shares 98% aa sequence identity with mouse and rat mGluR2.

  1. Conn P.J. and Pin J.P. (1997) Annu. Rev. Pharmacol. Toxicol. 37:205.
  2. Pin J.P. and Duvoisin R. (1995) Neuropharmacology. 34:1.
  3. Niswender C.M. and Conn P.J. (2010) Annu. Rev. Pharmacol. Toxicol. 50:295.
Long Name
Metabotropic Glutamate Receptor 2
Entrez Gene IDs
2912 (Human); 108068 (Mouse); 24415 (Rat)
Alternate Names
GLUR2; glutamate metabotropic receptor 2; glutamate receptor, metabotropic 2; GPRC1B; GPRC1Bmetabotropic glutamate receptor 2; GRM2; mGlu2; mGluR2; MGLUR2glutamate receptor homolog; mGluR7


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