Recombinant Human mGluR5 Protein, CF

Catalog # Availability Size / Price Qty
Product Details
Supplemental Products

Recombinant Human mGluR5 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Mouse myeloma cell line, NS0-derived human mGluR5 protein
Ser19-Ser509, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Structure / Form
Disuflide linked homodimer
Predicted Molecular Mass
56 kDa
61-71 kDa, reducing conditions

Complete Your Experiment

Product Datasheets

You must select a language.



Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: mGluR5

Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins and modulate glutamate neurotransmission in the central and peripheral nervous systems (1). Structurally, members from this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane, and a cytoplasmic carboxyl-terminal domain variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (3). Intracellularly, a short C-terminus interacts directly with a G-protein (2). The receptors are subdivided into three groups (I-III) based on sequence homology, signal transduction and pharmacological properties (1). Group I includes mGluR1 and mGluR5. This group has been shown to activate phospholipase C and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length. The 2-509 amino acids domain represents the ECD, with the apparent molecular mass approximately 64 kDa in SDS-PAGE under reducing conditions. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca++ sensor receptor (4). Over aa 2-509, human mGluR5 is 98% aa identical to mouse and rat mGluR5.

  1. Conn PJ, et al. (1997) Annu Rev Pharmacol Toxicol 37:205.
  2. Pin JP, et al. (1995) Neuropharmacology. 34:1.
  3. Niswender CM, et al. (2010) Annu Rev Pharmacol Toxicol 50:295.
  4. Doré AS, et al. (2014) Nature 511:557.
Long Name
Metabotropic Glutamate Receptor 5
Entrez Gene IDs
2915 (Human); 108071 (Mouse); 24418 (Rat)
Alternate Names
glutamate receptor, metabotropic 5; GPRC1E; GPRC1EMGLUR5metabotropic glutamate receptor 5; GRM5; mGlu5; mGluR5


No product specific FAQs exist for this product, however you may

View all Proteins and Enzyme FAQs

Reconstitution Buffers

Reviews for Recombinant Human mGluR5 Protein, CF

There are currently no reviews for this product. Be the first to review Recombinant Human mGluR5 Protein, CF and earn rewards!

Have you used Recombinant Human mGluR5 Protein, CF?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review