Recombinant Human mGluR8 Protein, CF

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Recombinant Human mGluR8 Protein, CF Bioactivity not tested
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Recombinant Human mGluR8 Protein, CF Summary

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Chinese Hamster Ovary cell line, CHO-derived human mGluR8 protein
Gln34-Ser514, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
No results obtained. Gln34 inferred from enzymatic pyroglutamate treatment revealing Glu35
Structure / Form
Disulfide linked homodimer
Predicted Molecular Mass
55 kDa
54-70 kDa, reducing conditions

Product Datasheets

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R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins.

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Background: mGluR8

Metabotropic glutamate receptors (mGluRs) are members of the G-protein-coupled receptor (GPCR) superfamily, modulating glutamate neurotransmission in the central and peripheral nervous systems through GTP-binding proteins (1). Structurally, members of this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane domains, and a cytoplasmic C-terminal domain that is variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (2). The C-terminal region is subject to alternative splicing, regulation by phosphorylation, and interacts directly with a G-protein to modulate protein-protein interactions (2, 3). The receptors are subdivided into three groups (I–III) based on sequence homology, signal transduction and pharmacological properties (1, 2). The Group III receptors include mGLuRs 4, 6, 7 and 8 (2). Mature human mGluR8 is 875 amino acids in length, including a 550 amino acid (aa) N-terminal ECD (4). Within N-terminal ECD, human mGluR8 shares 98.4% and 98.5% aa sequence identity with mouse and rat mGluR8, respectively.

  1. Conn P.J. and Pin J.P. (1997) Annu. Rev. Pharmacol. Toxicol. 37:205.
  2. Niswender C.M. and Conn P.J. (2010) Annu. Rev. Pharmacol. Toxicol. 50: 295.
  3. Pin J.P. and Duvoisin R. (1995) Neuropharmacology. 34:1.
  4. Wu S. et al. (1998) Brain Res. Mol. Brain Res. 53:88.
Long Name
Metabotropic Glutamate Receptor 8
Entrez Gene IDs
2918 (Human); 14823 (Mouse); 60590 (Rat)
Alternate Names
FLJ41058; glutamate metabotropic receptor 8; glutamate receptor, metabotropic 8; GPRC1H; GPRC1HMGLUR8GLUR8; GRM8; metabotropic glutamate receptor 8; MGC126724; mGlu8; mGluR8


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Primary Antibodies

His Tag Antibody

WB,Simple Western,Flow,AP,CyTOF-ready

Protein Purification Kits

Reconstitution Buffers

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