R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins.
glutamate receptors (mGluRs) are members of the G-protein-coupled receptor
(GPCR) superfamily, modulating glutamate neurotransmission in the central and
peripheral nervous systems through GTP-binding proteins (1). Structurally,
members of this family are characterized by a large N-terminal extracellular
domain (ECD), seven transmembrane domains, and a cytoplasmic C-terminal domain that
is variable in length. Two ECDs dimerize together and large conformational
changes are induced when agonists bind to one or both domains (2). The C-terminal region is subject to
alternative splicing, regulation by phosphorylation, and interacts directly
with a G-protein to modulate protein-protein interactions (2, 3). The receptors
are subdivided into three groups (I–III) based on sequence homology, signal
transduction and pharmacological properties (1, 2). The Group III receptors
include mGLuRs 4, 6, 7 and 8 (2). Mature human mGluR8 is 875 amino acids in
length, including a 550 amino acid (aa) N-terminal ECD (4). Within N-terminal ECD, human
mGluR8 shares 98.4% and 98.5% aa sequence identity with mouse and rat mGluR8,
Have you used Recombinant Human mGluR8 Protein, CF?
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