Recombinant Human MMP-2 Western Blot Standard Protein

R&D Systems | Catalog # WBC025

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Key Product Details

  • R&D Systems CHO-derived Recombinant Human MMP-2 Western Blot Standard Protein (WBC025)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

CHO

Applications

Western Blot
View all MMP-2 Proteins and Enzymes »

Formulation, Preparation, and Storage

WBC025
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: MMP-2

MMP-2 (matrix metalloproteinase 2), also known as Gelatinase A, is upregulated at sites of tissue damage, inflammation, and in stromal cells surrounding the invading front of metastatic tumors. The latent proenzyme (proMMP-2) is activated by MT-MMPs, Thrombin, or activated Protein C. Mature MMP-2 activity is inhibited by alpha 2-Macroglobulin or TIMPs 1, 2, 3, and -4. TIMP-2 and -3 can also tether proMMP-2 into cell surface ternary complexes with MT-MMPs. MMP-2 degrades Gelatin (denatured Collagen) and type IV Collagen, the major component of basement membranes. It can also degrade the matrix proteins Collagens V, VII and X, Decorin, Elastin, and Fibronectin. MMP-2 processes and modulates the functions of many other vasoactive and proinflammatory molecules including Adrenomedullin, Big Endothelin-1, Calcitonin gene-related peptide, CCL7/MCP-3, CXCL12/SDF-1, Galectin-3, IGFBP-3, IL-1 beta, S100A8, and S100A9.

Long Name

Matrix Metalloproteinase 2

Alternate Names

Gelatinase A, MMP2

Entrez Gene IDs

4313 (Human); 17390 (Mouse)

Gene Symbol

MMP2

Additional MMP-2 Products

Product Documents for Recombinant Human MMP-2 Western Blot Standard Protein

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human MMP-2 Western Blot Standard Protein

For research use only

Citations for Recombinant Human MMP-2 Western Blot Standard Protein

Customer Reviews for Recombinant Human MMP-2 Western Blot Standard Protein (2)

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  • Recombinant Human MMP-2 Western Blot Standard Protein
    Name: Anonymous
    Application: SDS-PAGE Control
    Verified Customer | Posted 07/03/2018
    Recombinant Human MMP-2 Western Blot Standard Protein WBC025
  • Recombinant Human MMP-2 Western Blot Standard Protein
    Name: Mizuho Kittaka
    Application: SDS-PAGE Control
    Verified Customer | Posted 04/12/2017
    Detected with anti-MMP2 antibody (ab37150)
    Recombinant Human MMP-2 Western Blot Standard Protein WBC025

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