Recombinant Human Neurexin 3 beta Fc Chimera Protein, CF

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Recombinant Human Neurexin 3 beta Fc Chimera Protein, CF Summary

Product Specifications

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. Biotinylated rrNLGN-1v2 immobilized on a streptavidin-coated plate at 2 µg/mL
(100 μL/well) can bind rhNeurexin 3 beta /Fc Chimera with an apparent KD <40 nM.
Mouse myeloma cell line, NS0-derived human Neurexin 3 beta/NRXN3b protein
Human Neurexin 3 beta
(Ser35 - Thr357)
Accession # NP_620426
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
61.1 kDa (monomer)
85-96 kDa, reducing conditions

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: Neurexin 3 beta/NRXN3b

The alpha and beta forms of Neurexins 1 - 3 are transmembrane neuronal glycoproteins which are transcribed from each of three NRXN genes that utilize alternate promoters. Like other Neurexins, the extracellular domain (ECD) of Neurexin 3 alpha contains six LNS domains interspersed with three EGF-like domains, while that of Neurexin 3 beta contains only the sixth LNS domain and no EGF-like domains (1 - 3). Mature human Neurexin 3 beta is a 70 kDa glycosylated protein with a 528 amino acid (aa) ECD and a 56 aa cytoplasmic domain that contains a motif for binding PDZ scaffolding proteins (3 - 5). Within comparable regions of the ECD, human Neurexin 3 beta shares 99% aa sequence identity with mouse and rat Neurexin 3 beta. It shares 65% aa sequence identity with comparable regions of the ECD of human Neurexin 1 beta and 2 beta. Alternative splicing of human Neurexin 3 beta generates multiple isoforms. There are potentially soluble and secreted variants and some which contain a fibronectin type III-like domain (4, 6). Neurexin 3 beta is widely expressed in the brain where it binds the postsynaptic Neuroligins 1, 2, and 3 (6 - 9). Neurexin 3 beta may also be expressed in non-nervous tissues with a potentially cardiac-specific isoform (10). Human Neurexin 3 beta polymorphisms which affect the splicing pattern are associated with susceptibility to alcohol dependence (6). The Neurexin 3 beta genetic locus has been linked to opioid and nicotine addiction, and Neurexin 3 beta gene expression is upregulated after short term exposure of mice to cocaine (11 - 13).

  1. Craig, A.M. and Y. Kang (2007) Curr. Opin. Neurobiol. 17:43.
  2. Dean, C. and T. Dresbach (2006) Trends Neurosci. 29:21.
  3. Lise, M.-F. and A. El-Husseini (2006) Cell. Mol. Life Sci. 63:1833.
  4. Rowen, L. et al. (2002) Genomics 79:587.
  5. Ushkaryov, Y. A. et al. (1994) J. Biol. Chem. 269:11987.
  6. Hishimoto, A. et al. (2007) Hum. Mol. Genet. 16:2880.
  7. Ullrich, B. et al. (1995) Neuron 14:497.
  8. Ichtchenko, K. et al. (1996) J. Biol. Chem. 271:2676.
  9. Ichtchenko, K. et al. (1995) Cell 81:435.
  10. Occhi, G. et al. (2002) Biochem. Biophys. Res. Commun. 298:151.
  11. Lachman, H.M. et al. (2007) Hum. Mol. Genet. 16:1327.
  12. Bierut, L.J. et al. (2007) Hum. Mol. Genet. 16:24.
  13. Kelai, S. et al. (2008) Neuroreport 19:751.
Entrez Gene IDs
9369 (Human); 18191 (Mouse)
Alternate Names
Neurexin 3 beta


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