Recombinant Human PARP Enzyme
Recombinant Human PARP Enzyme Summary
• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis
PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved in chromatin structure and DNA metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.
For research use only. Not for diagnositic use.
Citations for Recombinant Human PARP Enzyme
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NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
Authors: D Munnur, J Somers, G Skalka, R Weston, R Jukes-Jone, M Bhogadia, C Dominguez, K Cain, I Ahel, M Malewicz
Cell Rep, 2019;26(8):2028-2036.e6. 2019
Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
Authors: LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, KW Caldecott, AW Oliver, LH Pearl
Cell Rep, 2019;26(3):573-581.e5. 2019
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
Nucleic Acids Res, 0;41(3):1604-21. 0
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