Recombinant Human PARP Enzyme

Catalog #: 4668-02K-01
3 Citations Datasheet / COA / SDS

Discontinued Product

4668-02K-01 has been discontinued.
View all PARP products.
Product Details
Citations (3)

Recombinant Human PARP Enzyme Summary

Provides the High specific activity PARP1 (PARP-HSA) is used in the Universal or PARP/Apoptosis Assay Kits.

Key Benefits

• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis

Substrate Specificity

PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved  in  chromatin  structure  and  DNA  metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.


10 units/µl


Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


For research use only. Not for diagnostic use.

Product Datasheets

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Citations for Recombinant Human PARP Enzyme

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
    Authors: D Munnur, J Somers, G Skalka, R Weston, R Jukes-Jone, M Bhogadia, C Dominguez, K Cain, I Ahel, M Malewicz
    Cell Rep, 2019;26(8):2028-2036.e6.  2019
  2. Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
    Authors: LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, KW Caldecott, AW Oliver, LH Pearl
    Cell Rep, 2019;26(3):573-581.e5.  2019
  3. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
    Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
    Nucleic Acids Res, 0;41(3):1604-21.  0


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