When Recombinant Human PVRIG Fc Chimera (Catalog # 9365-PV)is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Nectin‑2/CD112 (Catalog # 2229-N2) binds with an ED50 of 0.4-2.4 μg/mL.
Human PVRIG (poliovirus
receptor related immunoglobulin domain-containing protein), also known as CD112
receptor (CD112R), is an approximately 34 kDa single
transmembrane protein in the poliovirus receptor-like
protein (PVR) family (1). It is composed of a single extracellular
IgV domain, one transmembrane domain, and a long intracellular domain. The
intracellular domain contains two tyrosine residues, one within an ITIM-like
motif that is a potential docking site for phosphatases (1). The extracellular domain sequence
of human and mouse PVRIG have approximately 65% similarity. The human PVRIG
gene is preferentially expressed in lymphocytes, such as T cells and NK cells,
but not in monocyte derived dendritic cells (1). PVRIG functions as a cell
surface receptor for Nectin-2/CD112, a cell surface protein that is widely
expressed on antigen-presenting cells and tumor cells. Disrupting the
PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is
a novel checkpoint for human T cells (1).
Zhu, Y., et.al. (2016) J. Exp. Med. 213:167.
Poliovirus Receptor Related Immunoglobulin Domain Containing
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