Recombinant Human PVRIG Fc Chimera Protein, CF

  
  • Accession #
  • N-terminal Sequence
    Analysis
    Thr41 & Glu43
  • Structure / Form
    Disulfide-linked homodimer
  • Predicted Molecular Mass
    40 kDa
  • SDS-PAGE
    51-57 kDa, reducing conditions
9365-PV
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Data Images
When Recombinant Human PVRIG Fc Chimera (Catalog #
9365-PV)is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Nectin‑2/CD112 (Catalog #
2229-N2) binds with an ED50 of 0.4-2.4 μg/mL.
Background: PVRIG
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family (1). It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases (1). The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells (1). PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells (1).
  • References:
    1. Zhu, Y., et.al. (2016) J. Exp. Med. 213:167.
  • Long Name:
    Poliovirus Receptor Related Immunoglobulin Domain Containing
  • Entrez Gene IDs:
    79037 (Human); 620147 (Mouse)
  • Alternate Names:
    C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVRIG; transmembrane protein PVRIG
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