1 μg/lane ofRecombinant Human Reg1B (Catalog # 2090-RG)was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditionsand visualized by silver staining, showing bands at 17.2 and 16.7 kDa, respectively.
Reg1B also called Lithostatine-1-beta or Pancreatic stone protein 2 (PSP2) is a type I subclass member of the Reg gene family. The Reg multigene family consists of four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins of the genes. Reg1B is also a member of the Reg family of secreted C-type lectin domain-containing pancreatic proteins (1, 2). The human Reg1B cDNA encodes 166 amino acids protein which contains a 22 aa signal peptide and the 144 aa secreted mature protein. Reg1B shares 86% animo acide sequence identity with Reg1A and like Reg1A is secreted by the exocrine pancreas and associated with islet cell regeneration and diabetogenesis. Reg family proteins were also shown to cause Schwann cell proliferation during regeneration of motor neurons (3).
Liu, J.-L. et al. (2008) Endocrine Metab. Immune Disord. Drug Targets 8:1.
Unno, M. et al. (1993) J. Biol. Chem. 268:15974.
Livesey F.J. et al. (1990) Nature. 390:614.
Regenerating Islet-derived 1B
Entrez Gene IDs:
Lithostathine 1 beta; lithostathine-1-beta; Pancreatic stone protein 2; pancreatic threadprotein); PSPS2; PSPS2PSP-2; Reg1B; regenerating islet-derived 1 beta; Regenerating islet-derived protein 1-beta; Regenerating protein I beta; REGH; REGLREG-1-beta; secretory pancreatic stone protein 2
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