Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha

(102 citations)
(1 Review)
  
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED50 for this effect is 3‑9 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR4. The ED50 for this effect is 0.15‑0.6 ng/mL.
  • Source
    E. coli-derived Lys22-Lys89
  • Accession #
  • N-terminal Sequence
    Analysis
    Lys22
  • Predicted Molecular Mass
    8.0 kDa
  • SDS-PAGE
    7 kDa, reducing conditions.
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
350-NS
 
350-NS/CF
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images

Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro-B cells transfected with human CXCR4. The ED50 for this effect is 0.15-0.6 ng/mL.

1 μg/lane of Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha  was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.
Background: CXCL12/SDF-1 alpha

SDF-1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell-dependent pre-B-cell line.
SDF-1 alpha  and SDF-1 beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. SDF-1 alpha and SDF-1 beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 beta and absent from SDF-1 alpha. The amino acid sequence of SDF-1/PBSF identified the protein to be a member of the chemokine alpha subfamily that lacks the ELR domain. Unlike other known chemokine alpha and beta subfamily members that cluster on chromosomes 4 and 17, respectively, SDF-1/PBSF was mapped to chromosome 10q11.1. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF has been found to be a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. SDF-1/PBSF was shown to be a ligand for CXCR4 (fusin/LESTR) receptor that functions as a co-receptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF has been found to be a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.

  • References:
    1. Tashiro, K. et al. (1993) Science 261:600.
    2. Bleul, C. et al. (1996) Nature 382:829.
    3. Oberlin, E. et al. (1996) Nature 382:833.
  • Entrez Gene IDs:
    6387 (Human); 20315 (Mouse); 493806 (Feline)
  • Alternate Names:
    CXCL12 chemokine (C-X-C motif) ligand 12; CXCL12/SDF-1 alpha; IRH; PBSF; SCYB12; SDF1 alpha; SDF1; SDF1a; SDF1B; TLSF; TPAR1
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

102 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis
    Authors: H Al Faruque, JH Kang, SR Hwang, S Sung, MM Alam, KH Sa, EJ Nam, YR Byun, YM Kang
    PLoS ONE, 2017;12(4):e0176110.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  2. A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies
    Authors: DI Bromage, S Taferner, M Pillai, DM Yellon, SM Davidson
    PLoS ONE, 2017;12(4):e0174447.
    Species: Human
    Sample Type: Antibody
    Application: EnzAct
  3. Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease
    Authors: X Liu, Y Liu, X Huang, G Lin, C Xie
    Mol Med Rep, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  4. Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury
    Authors: W Chen, S Ju, T Lu, Y Xu, X Zheng, H Wang, Y Ge, S Ju
    Cytokine, 2017;95(0):27-34.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Hepatitis B virus X protein promotes the stem-like properties of OV6(+) cancer cells in hepatocellular carcinoma
    Authors: C Wang, MD Wang, P Cheng, H Huang, W Dong, WW Zhang, PP Li, C Lin, ZY Pan, MC Wu, WP Zhou
    Cell Death Dis, 2017;8(1):e2560.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. MicroRNA expression profiles and networks in CXCL12?stimulated human endometrial stromal cells
    Mol Med Rep, 2017;15(1):249-255.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. Designed cell consortia as fragrance-programmable analog-to-digital converters
    Authors: M Müller, S Ausländer, A Spinnler, D Ausländer, J Sikorski, M Folcher, M Fussenegge
    Nat. Chem. Biol, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells
    Authors: M Moslem, R Eggenschwi, C Wichmann, R Buhmann, T Cantz, R Henschler
    Stem Cells Int, 2017;2017(0):7316354.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  9. Frontline Science: CXCR7 mediates CD14(+)CD16(+) monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS
    Authors: M Veenstra, DW Williams, TM Calderon, K Anastos, S Morgello, JW Berman
    J. Leukoc. Biol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. PLC?1 regulates SDF-1?-induced lymphocyte adhesion and migration to sites of inflammation
    Authors: M Strazza, I Azoulay-Al, M Peled, AV Smrcka, EY Skolnik, S Srivastava, A Mor
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B-cells from apoptosis, enhance their migration and induce gene expression modifications
    Authors: E Crompot, M Van Damme, K Pieters, M Vermeersch, D Perez-Morg, P Mineur, M Maerevoet, N Meuleman, D Bron, L Lagneaux, B Stamatopou
    Haematologica, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate
    Authors: PJ Stewart-Hu, TP Szasz, ER Jaeger, MD Onken, JA Cooper, SC Morley
    J. Leukoc. Biol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor
    Authors: R Desplantes, C Lévêque, B Muller, M Lotierzo, G Ferracci, M Popoff, M Seagar, R Mamoun, O El Far
    Sci Rep, 2017;7(1):1032.
    Species: Human
    Sample Type: Recombinant Protein
    Application: Bioassay
  14. Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
    Authors: JH Kim, JW Shim, DY Eum, SD Kim, SH Choi, K Yang, K Heo, MT Park
    Sci Rep, 2017;7(1):2798.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  15. CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells
    Authors: M Zhang, L Qiu, Y Zhang, D Xu, JC Zheng, L Jiang
    Sci Rep, 2017;7(1):8289.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  16. Regulation of CCR7-dependent cell migration through�CCR7 homodimer formation
    Authors: D Kobayashi, M Endo, H Ochi, H Hojo, M Miyasaka, H Hayasaka
    Sci Rep, 2017;7(1):8536.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. HEREGULIN/ErbB3 SIGNALING ENHANCES CXCR4-DRIVEN Rac1 ACTIVATION AND BREAST CANCER CELL MOTILITY VIA HIF-1?
    Mol Cell Biol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  18. SDF-1?-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia
    Sci Rep, 2016;6(0):34416.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: Evidence for Partial Allosteric Agonism in Comparison to CXCL12
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  20. Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis
    Authors: S Velasquez, S Malik, SE Lutz, E Scemes, EA Eugenin
    J Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation
    Authors: Patricia Freund
    PLoS ONE, 2016;11(6):e0156693.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. Local CXCR4 Up-regulation in Injured Arterial Wall Contributes to Intimal Hyperplasia
    Authors: Xudong Shi
    Stem Cells, 2016;0(0):.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  23. Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia.
    Authors: Janovska P, Poppova L, Plevova K, Plesingerova H, Behal M, Kaucka M, Ovesna P, Hlozkova M, Borsky M, Stehlikova O, Brychtova Y, Doubek M, Machalova M, Baskar S, Kozubik A, Pospisilova S, Pavlova S, Bryja V
    Clin Cancer Res, 2016;22(2):459-69.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. CXCL12-gamma in primary tumors drives breast cancer metastasis.
    Authors: Ray P, Stacer A, Fenner J, Cavnar S, Meguiar K, Brown M, Luker K, Luker G
    Oncogene, 2015;34(16):2043-51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
    Authors: Chang T, Poltoratsky V, Vancurova I
    J Immunol, 2015;194(6):2942-53.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis.
    Authors: Heinzmann D, Bangert A, Muller A, von Ungern-Sternberg S, Emschermann F, Schonberger T, Chatterjee M, Mack A, Klingel K, Kandolf R, Malesevic M, Borst O, Gawaz M, Langer H, Katus H, Fischer G, May A, Kaya Z, Seizer P
    PLoS ONE, 2015;10(4):e0124606.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. SDF-1alpha is a novel autocrine activator of platelets operating through its receptor CXCR4.
    Authors: Walsh T, Harper M, Poole A
    Cell Signal, 2015;27(1):37-46.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  28. JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals.
    Authors: Williams D, Anastos K, Morgello S, Berman J
    J Leukoc Biol, 2015;97(2):401-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
    Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
    Nat Med, 2015;21(5):530-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration.
    Authors: Lessey-Morillon E, Osborne L, Monaghan-Benson E, Guilluy C, O'Brien E, Superfine R, Burridge K
    J Immunol, 2014;192(7):3390-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I.
    Authors: Watson H, Holley R, Langford-Smith K, Wilkinson F, van Kuppevelt T, Wynn R, Wraith J, Merry C, Bigger B
    J Biol Chem, 2014;289(52):36194-203.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. CXCR7 controls competition for recruitment of beta-arrestin 2 in cells expressing both CXCR4 and CXCR7.
    Authors: Coggins N, Trakimas D, Chang S, Ehrlich A, Ray P, Luker K, Linderman J, Luker G
    PLoS ONE, 2014;9(6):e98328.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  33. Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia.
    Authors: Zucco L, Zhang Q, Kuliszewski M, Kandic I, Faughnan M, Stewart D, Kutryk M
    PLoS ONE, 2014;9(2):e89927.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  34. The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization.
    Authors: Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M, Kruschinski A, Burger J
    Blood, 2014;123(7):1032-9.
    Species: N/A
    Sample Type: Chip
    Application: Bioassay
  35. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Authors: Butschkau, Antje, Wagner, Nana-Mar, Genz, Berit, Vollmar, Brigitte
    PLoS ONE, 2014;9(12):e113554.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. A paracrine network regulates the cross-talk between human lung stem cells and the stroma.
    Authors: Ruiz E, Oeztuerk-Winder F, Ventura J
    Nat Commun, 2014;5(0):3175.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  37. TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
    Authors: Lo H, Lai T, Li C, Wu W
    Acta Pharmacol Sin, 2014;35(3):339-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  38. Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.
    Authors: Krook M, Nicholls L, Scannell C, Chugh R, Thomas D, Lawlor E
    Mol Cancer Res, 2014;12(6):953-64.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells.
    Authors: Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar J, Garcia-Marco J, Garcia-Pardo A
    J Biol Chem, 2014;289(22):15340-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.
    Authors: Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, Leveque J, Tas P, Le Drean Y, Pakdel F
    BMC Cancer, 2014;14(0):407.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells.
    Authors: Vermi W, Micheletti A, Lonardi S, Costantini C, Calzetti F, Nascimbeni R, Bugatti M, Codazzi M, Pinter P, Schakel K, Tamassia N, Cassatella M
    Nat Commun, 2014;5(0):3029.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.
    Authors: Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit M, Blanchet X, von Hundelshausen P, Weber C, Forssmann W, Henschler R
    Stem Cells Dev, 2014;23(16):1959-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. Carbon monoxide down-regulates alpha4beta1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.
    Authors: Chigaev A, Smagley Y, Sklar L
    BMC Immunol, 2014;15(0):52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  44. Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.
    Authors: Westerweel, Peter E, Teraa, Martin, Rafii, Shahin, Jaspers, Janneke, White, Ian A, Hooper, Andrea T, Doevendans, Pieter A, Verhaar, Marianne
    PLoS ONE, 2014;8(3):e60357.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  45. Complex cellular composition of solitary fibrous tumor of the prostate.
    Authors: Gharaee-Kermani M, Mehra R, Robinson D, Wei J, Macoska J
    Am J Pathol, 2014;184(3):732-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
    Authors: Smith A, Bowers S, Stratman A, Davis G
    PLoS ONE, 2013;8(12):e85147.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. Distinct angiogenesis roles and surface markers of early and late endothelial progenitor cells revealed by functional group analyses.
    Authors: Cheng, Cheng-Ch, Chang, Shing-Jy, Chueh, Yu-Neng, Huang, Tse-Shun, Huang, Po-Hsun, Cheng, Shu-Meng, Tsai, Tsung-Ne, Chen, Jaw-Wen, Wang, Hsei-Wei
    BMC Genomics, 2013;14(0):182.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture.
    Authors: Hoque, Md Tamji, Windus, Louisa C, Lovitt, Carrie J, Avery, Vicky M
    PLoS ONE, 2013;8(11):e79865.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  49. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
    Authors: Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco F, Langa C, Botella L, Cabanas C, Lopez-Novoa J, Bernabeu C
    Blood, 2013;121(2):403-15.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro.
    Authors: Wen W, Xie S, Xin X, Geng M, Ding J, Chen Y
    Acta Pharmacol Sin, 2013;34(12):1554-9.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  51. Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.
    Authors: Akimoto, Keiko, Kimura, Kenichi, Nagano, Masumi, Takano, Shingo, To'a Salazar, Georgina, Yamashita, Toshihar, Ohneda, Osamu
    Stem Cells Dev, 2013;22(9):1370-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
    Authors: Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao J, Cagnetta A, Cea M, Sellitto M, Zhong M, Wang Q, Acharya C, Carrasco D, Buggy J, Elias L, Treon S, Matsui W, Richardson P, Munshi N, Anderson K
    Blood, 2012;120(9):1877-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  55. Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.
    Authors: Burton VJ, Butler LM, McGettrick HM, Stone PC, Jeffery HC, Savage CO, Rainger GE, Nash GB
    Exp. Cell Res., 2011;317(3):276-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
    Authors: Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S
    Clin. Cancer Res., 2011;17(11):3619-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors.
    Authors: Fujio M, Yamamoto A, Ando Y, Shohara R, Kinoshita K, Kaneko T, Hibi H, Ueda M
    Bone, 2011;49(4):693-700.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  58. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
    Authors: Fujita-Sato S, Ito S, Isobe T, Ohyama T, Wakabayashi K, Morishita K, Ando O, Isono F
    J. Biol. Chem., 2011;286(36):31409-17.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  59. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
    Authors: Badr G, Lefevre EA, Mohany M
    PLoS ONE, 2011;6(9):e23741.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. Analgesic efficacy of buprenorphine in the presence of high levels of SDF-1alpha/CXCL12 in the brain.
    Authors: Benamar K, Palma J, Cowan A, Geller EB, Adler MW
    Drug Alcohol Depend, 2011;114(2):246-8.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  61. CXCR7 protein is not expressed on human or mouse leukocytes.
    Authors: Berahovich RD, Zabel BA, Penfold ME, Lewen S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ
    J. Immunol., 2010;185(9):5130-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Competitive Binding Assay
  62. Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
    Authors: Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L
    J. Invest. Dermatol., 2010;130(6):1646-56.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  63. Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen.
    Authors: Hachehouche LN, Chetoui N, Aoudjit F
    Mol. Immunol., 2010;47(9):1866-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization.
    Authors: Sengupta N, Afzal A, Caballero S, Chang KH, Shaw LC, Pang JJ, Bond VC, Bhutto I, Baba T, Lutty GA, Grant MB
    Invest. Ophthalmol. Vis. Sci., 2010;51(5):2697-704.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  65. Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
    Authors: Kenig S, Alonso MB, Mueller MM, Lah TT
    Cancer Lett., 2010;289(1):53-61.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
    Authors: Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N
    Cancer Cell, 2009;15(1):21-34.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  67. Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
    Authors: Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
    J. Immunol., 2009;182(1):666-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin.
    Authors: Skrzeczynska-Moncznik J, Wawro K, Stefanska A, Oleszycka E, Kulig P, Zabel BA, Sulkowski M, Kapinska-Mrowiecka M, Czubak-Macugowska M, Butcher EC, Cichy J
    Biochem. Biophys. Res. Commun., 2009;380(2):323-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
    Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
    FASEB J., 2009;23(9):2928-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
    Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
    J. Exp. Med., 2009;206(3):535-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
    Authors: Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE
    Blood, 2009;114(24):5091-101.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo.
    Authors: Kerfoot SM, Andonegui G, Bonder CS, Liu L
    Am. J. Physiol. Heart Circ. Physiol., 2008;294(6):H2524-34.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  73. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
    Authors: Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S
    Eur. J. Immunol., 2008;38(11):3050-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  74. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
    Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
    J. Immunol., 2008;181(11):8053-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  75. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.
    Authors: Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M
    J. Clin. Invest., 2007;117(9):2526-38.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  76. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  77. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
    Authors: Bayry J, Triebel F, Kaveri SV, Tough DF
    J. Immunol., 2007;178(7):4184-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.
    Authors: Schreiber TH, Shinder V, Cain DW, Alon R, Sackstein R
    Blood, 2007;109(4):1381-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells.
    Authors: Kaminski A, Ma N, Donndorf P, Lindenblatt N, Feldmeier G, Ong LL, Furlani D, Skrabal CA, Liebold A, Vollmar B, Steinhoff G
    Lab. Invest., 2007;88(1):58-69.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  80. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.
    Authors: Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT
    J. Immunol., 2007;179(7):4661-71.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain.
    Authors: Isakova IA, Baker K, Dutreil M, Dufour J, Gaupp D, Phinney DG
    Stem Cells, 2007;25(12):3261-70.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  82. Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
    Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
    Nature, 2007;450(7171):825-31.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  83. Novel antiviral activity of chemokines.
    Authors: Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O
    Virology, 2006;350(2):484-92.
    Species: Virus
    Sample Type: Virus
    Application: Binding Assay
  84. Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
    Authors: Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan AI, Facchini A
    J. Cell. Physiol., 2006;207(2):364-73.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  85. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
    Authors: Nakayama T, Mutsuga N, Tosato G
    Blood, 2006;109(4):1363-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
    Authors: Carr AN, Howard BW, Yang HT, Eby-Wilkens E, Loos P, Varbanov A, Qu A, DeMuth JP, Davis MG, Proia A, Terjung RL, Peters KG
    Cardiovasc. Res., 2006;69(4):925-35.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  87. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
    Authors: Infantino S, Moepps B, Thelen M
    J. Immunol., 2006;176(4):2197-207.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  88. Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
    Authors: Carr AN, Howard BW, Yang HT, Eby-Wilkens E, Loos P, Varbanov A, Qu A, DeMuth JP, Davis MG, Proia A, Terjung RL, Peters KG
    Cardiovasc. Res., 2006;69(4):925-35.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  89. HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
    Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
    Glia, 2006;54(6):619-29.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  90. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.
    Authors: Saunders WB, Bohnsack BL, Faske JB, Anthis NJ, Bayless KJ, Hirschi KK, Davis GE
    J. Cell Biol., 2006;175(1):179-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  91. Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles.
    Authors: Anghelina M, Krishnan P, Moldovan L, Moldovan NI
    Am. J. Pathol., 2006;168(2):529-41.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  92. Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells.
    Authors: Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, Strazzer S, Salani S, Bresolin N, Comi GP
    FASEB J., 2005;19(13):1860-2.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  93. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
    Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
    Arthritis Rheum., 2005;52(5):1504-16.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  94. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis.
    Authors: Janardhan A, Swigut T, Hill B, Myers MP, Skowronski J
    PLoS Biol., 2004;2(1):E6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
    Authors: Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
    Blood, 2004;104(1):65-72.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  96. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
    Authors: Curiel, Tyler J, Coukos, George, Zou, Linhua, Alvarez, Xavier, Cheng, Pui, Mottram, Peter, Evdemon-Hogan, Melina, Conejo-Garcia, Jose R, Zhang, Lin, Burow, Matthew, Zhu, Yun, Wei, Shuang, Kryczek, Ilona, Daniel, Ben, Gordon, Alan, Myers, Leann, Lackner, Andrew, Disis, Mary L, Knutson, Keith L, Chen, Lieping, Zou, Weiping
    Nat Med, 2004;10(9):942-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  97. Development of a novel surrogate virus for human T-cell leukemia virus type 1: inhibition of infection by osteoprotegerin.
    Authors: Okuma K, Dalton KP, Buonocore L, Ramsburg E, Rose JK
    J. Virol., 2003;77(15):8562-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  98. Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
    Authors: Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
    J. Leukoc. Biol., 2003;74(5):880-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  99. Expression of functional CCR and CXCR chemokine receptors in podocytes.
    Authors: Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstadt H
    J. Immunol., 2002;168(12):6244-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  100. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
    Authors: Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S
    Cell, 2002;109(5):625-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  101. Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes.
    Authors: Zamarchi R, Allavena P, Borsetti A, Stievano L, Tosello V, Marcato N, Esposito G, Roni V, Paganin C, Bianchi G, Titti F, Verani P, Gerosa G, Amadori A
    Clin. Exp. Immunol., 2002;127(2):321-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  102. A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis.
    Authors: Misse D, Cerutti M, Noraz N, Jourdan P, Favero J, Devauchelle G, Yssel H, Taylor N, Veas F
    Blood, 1999;93(8):2454-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
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Average Rating: 5 (Based on 1 review)

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Cell migration/motility Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha 350-NS
Cell migration/motility: Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha [350-NS]

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