Recombinant Human SHBG Protein, CF

R&D Systems | Catalog # 9614-SG

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Key Product Details

  • R&D Systems NS0-derived Recombinant Human SHBG Protein (9614-SG)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

NS0

Accession Number

P04278-1
View all SHBG Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived human SHBG protein
Leu30-His402, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu30

Predicted Molecular Mass

41 kDa

SDS-PAGE

41-52 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation, and Storage

9614-SG
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: SHBG

Human SHBG (Sex hormone-binding globulin), also known as ABP (Testis-specific Androgen-binding protein) or TeBG (Testosterone-estradiol-binding globulin), is a variably glycosylated, secreted non-disulfide linked homodimer that belongs to the SHBG family (1). Members of this small family have tandem repeats of 170 amino acid (aa) long laminin alpha chain G‑ like domains. Each SHBG monomer is a 47-53 kDa, 373 aa glycoprotein that contains one steroid-binding site in its N-terminal G‑ like domain (2). SHBG is synthesized by the liver and circulates in blood. It binds to certain androgens and estrogens and serves as a transporter for the bound steroids (3); it is also involved in receptor mediated processes (4). Human SHBG shares approximately 67% aa sequence identity with mouse and rat SHBG. Low SHGB levels are associated with increased risk for type 2 diabetes for both man and women (5).

References

  1. Awakumov G.V. et al. (2010) Mol. Cell Endocrinol. 5:316.
  2. Grishkovskaya I. et al. (2000) EMBO J. 19:504.
  3. Anderson D.C. (1974) Clin. Endocrinol. (Oxf.) 3:69.
  4. Rosner W. et al. (2010) Mol. Cell Endocrinol.5:795.
  5. Muka T. et al. (2017) Diabetes. 66:577.

Long Name

Sex Hormone-binding Globulin

Alternate Names

ABP

Entrez Gene IDs

6462 (Human)

Gene Symbol

SHBG

UniProt

P04278-1

Additional SHBG Products

Product Documents for Recombinant Human SHBG Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human SHBG Protein, CF

For research use only

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