Recombinant Human Stabilin-2 His-tag Protein, CF

Catalog # Availability Size / Price Qty
Recombinant Human Stabilin‑2 His-tag Protein Binding Activity.
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Product Details

Recombinant Human Stabilin-2 His-tag Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human Stabilin-2 His-tag Protein is immobilized at 2.00 μg/mL (100 μL/well), Biotinylated Hyaluronan binds with an ED50 of 1.50-7.50 ng/mL.
Chinese Hamster Ovary cell line, CHO-derived human Stabilin-2 protein
Ser20-Thr2458, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Predicted Molecular Mass
265 kDa
260-300 kDa, under reducing conditions.

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity View Larger

When Recombinant Human Stabilin-2 His-tag Protein (Catalog # 11086-S2) is immobilized at 2.00 μg/mL (100 μL/well), Biotinylated Hyaluronan binds with an ED50 of 1.50-7.50 ng/mL.

SDS-PAGE View Larger

2 μg/lane of Recombinant Human Stabilin‑2 His-tag Protein (Catalog # 11086-S2) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 260-300 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: Stabilin-2

Stabilin­-2, also known as HARE (Hyaluronic Acid Receptor for Endocytosis) and FEEL­2 (Fasciclin, EGF­-like, laminin type EGF­-like, and Link domain containing scavenger receptor 2), is a type I transmembrane multi­domain protein that is the closest homolog of stabilin­1. It is a scavenger receptor that is expressed on sinusoidal endothelial cells of liver, spleen, and lymph node (1, 2). Its 2439 amino acid (aa) extracellular domain contains seven fasciclin domains, multiple EGF-­like and laminin type EGF-­like domains, and a link domain related to molecules of the TSG­6 superfamily (3). The 72 aa cytoplasmic tail of Stabilin­2 contains a motif that allows the AP2 classical cargo adaptor to direct cargo into clathrin­coated pits (4). Stabilin­2 also mediates the endocytosis of chondroitin and chondroitin sulfate, advanced glycosylation end­product (AGE), collagen N­terminal propeptides and acetylated LDL (4-7). Stabilin-2 has been found to regulate the cancer progression, and high expression of Stabilin-2 was reported to predict poor tumor prognosis in NSCLC (8).

  1. Politz, O. et al. (2002) Biochem. J. 362:155.
  2. Harris, E.N. and F. Cabral (2019) Biomolecules 9:273.
  3. Blundell, C.D. et al. (2005) J. Biol. Chem. 280:18189.
  4. Hansen, B. et al. (2005) Exp. Cell Res. 303:160.
  5. Harris, E.N. et al. (2004) J. Biol. Chem. 279:36201.
  6. Harris, E.N. et al. (2007) J. Biol. Chem. 282:2785.
  7. Tamura, Y. et al. (2003) J. Biol. Chem. 278:12613.
  8. Yong, J. et al. (2021) Bioengineered 12:3426.
Entrez Gene IDs
55576 (Human); 192188 (Mouse); 282580 (Rat)
Alternate Names
CD44-like precursor FELL; DKFZP434E0321; FAS1 EGF-like and X-link domain containing adhesion molecule-2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 2; FEEL2; FEEL-2; FELE-2; FELL; FELL-2; FEX2; HARE; HAREFELL2; hepatic hyaluronan clearance receptor; Hyaluronan receptor for endocytosis; hyaluronic acid receptor for endocytosis; STAB2; STAB-2; stabilin 2; Stabilin2; Stabilin-2


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