Recombinant Human Stanniocalcin 1/STC-1 Protein, CF
Recombinant Human Stanniocalcin 1/STC-1 Protein, CF Summary
Thr18-Ala247, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: Stanniocalcin 1/STC-1
Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius (1-3). In contrast to fish where expression is mainly in the corpuscles of Stannius, the STC-1 gene in mammals is widely expressed in tissues including thyroid, ovary, prostate, adrenal gland, muscle, intestine, kidney, heart and lung (4). Human STC-1 protein consists of a 16 amino acid (aa) propeptide region and a 214 aa STC-1 chain. The amino acid sequence of human mature STC-1 is 36% identical to that of human STC-2. STC-1 is highly homologous with mouse, sharing 95% amino acid identity. STC-1 inhibits the breakdown of PAPP-A (5), protects cancer cells from apoptosis (4), reduces tumor size of liver cancers (6), promotes osteoblast differentiation (7) and inhibits longitudinal bone growth directly at the growth plate (8). It is also a biomarker of brain and lung cancer progression (7, 8).
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- Kloverpris S, et al. (2015) J Biol Chem. 290:21915.
- Yeung BH, et al. (2015) PLoS One. 10:e0139977.
- Su J, et al. (2015) Tumour Biol. 36:6333.
- Du YZ, et al. (2016) Tumour Biol. 37:5633.
Citation for Recombinant Human Stanniocalcin 1/STC-1 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway
Authors: F Zhao, LX Feng, Q Liu, HS Wang, CY Tang, W Cheng, YH Deng, X Wu, P Yan, XJ Duan, JC Peng, SB Duan
Oxid Med Cell Longev, 2020;2020(0):1898213.
Sample Types: Whole Cells
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