Recombinant Human TDP-43/TARDBP Protein, CF
Recombinant Human TDP-43/TARDBP Protein, CF Summary
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||X mg/ml (X μM) in 50 mM HEPES pH 8.0, 500 mM NaCl, 5 mM DTT, 20% (v/v) Glycerol, 0.4 M Urea|
|Shipping||The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates--along with a truncated 20-28 kDa form--in the Ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Human TDP-43 is 96% identical to the mouse ortholog.
- Buratti E. et al. (2001) EMBO J. 20: 1774
- Chen-Plotkin A.S. et al. (2010) Nat. Rev. Neurol. 6: 211
- Johnson B.S. et al. (2009) J. Biol. Chem. 284: 20329
- Strong M.J. et al. (2007) Mol. Cell Neurosci. 35: 320
No product specific FAQs exist for this product, however you mayView all Proteins and Enzyme FAQs
Reviews for Recombinant Human TDP-43/TARDBP Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Human TDP-43/TARDBP Protein, CF and earn rewards!
Have you used Recombinant Human TDP-43/TARDBP Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image