Recombinant Human TDP-43/TARDBP Protein, CF

R&D Systems | Catalog # AP-190

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Key Product Details

  • R&D Systems E. coli-derived Recombinant Human TDP-43/TARDBP Protein (AP-190)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

E. coli

Accession Number

NP_031401.1

Applications

Bioactivity
View all TDP-43/TARDBP Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human TDP-43/TARDBP protein

Predicted Molecular Mass

45 kDa

Activity

Typical protein concentration for in vitro use depends on the specific application.

Reviewed Applications

Read 2 reviews rated 4.5 using AP-190 in the following applications:

Formulation, Preparation, and Storage

AP-190
Formulation Supplied as a solution in HEPES, NaCl, DTT, Glycerol and Urea.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: TDP-43/TARDBP

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing.  TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration.  In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in the Ubiquitin-containing inclusion bodies.  TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis.  Human TDP-43 is 96% identical to the mouse ortholog.

References

  1. Buratti E. et al. (2001) EMBO J.  20: 1774.
  2. Chen-Plotkin A.S. et al. (2010) Nat. Rev. Neurol.  6: 211.
  3. Johnson B.S. et al. (2009) J. Biol. Chem.  284: 20329.
  4. Strong M.J. et al. (2007) Mol. Cell Neurosci.  35: 320.
 

Long Name

TAR DNA-binding Protein 43

Alternate Names

ALS10, TARDBP, TDP43

Entrez Gene IDs

23435 (Human)

Gene Symbol

TARDBP

UniProt

NP_031401.1

Additional TDP-43/TARDBP Products

Product Documents for Recombinant Human TDP-43/TARDBP Protein, CF

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Recombinant Human TDP-43/TARDBP Protein, CF

For research use only

Related Research Areas

Infectious Diseases

Citations for Recombinant Human TDP-43/TARDBP Protein, CF

Customer Reviews for Recombinant Human TDP-43/TARDBP Protein, CF (2)

4.5 out of 5
2 Customer Ratings
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  • Recombinant Human TDP-43/TARDBP Protein, CF
    Name: Anna Chaly
    Application: Cleavage by caspase-7
    Verified Customer | Posted 06/26/2025
    Protein was detected with anti-TDP43 antibody. Lane 1 uncut, Lanes 2-4 with Caspase-7. Chameleon Duo Pre-stained Protein Ladder
    Recombinant Human TDP-43/TARDBP Protein, CF AP-190
  • Recombinant Human TDP-43/TARDBP Protein, CF
    Name: Laura Kropp
    Application: high-resolution respirometry
    Verified Customer | Posted 09/21/2022
    Recombinant Human TDP-43/TARDBP Protein, CF AP-190

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FAQs for Recombinant Human TDP-43/TARDBP Protein, CF

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  • Q: Does the Recombinant Human TDP-43/TARDBP Protein (Catalog # AP-190-100) contain a tag?

    A:

    AP-190 is the full-length protein and it does not contain any tags. The predicted molecular mass for this protein is 45 kDa, which matches the sequence stated in the datasheet linked here: https://www.ncbi.nlm.nih.gov/protein/NP_031401.1

  • Q: Why is this protein supplied with 0.4 M urea in the formulation buffer?

    A: Without the presence of urea, this protein would be insoluble. This is partially due to the expression system and the nature of the protein. Any attempt to dilute the urea down will cause the protein to precipitate.

  • Q: Does the Recombinant Human TDP-43/TARDBP Protein (Catalog # AP-190-100) contain a tag?

    A:

    AP-190 is the full-length protein and it does not contain any tags. The predicted molecular mass for this protein is 45 kDa, which matches the sequence stated in the datasheet linked here: https://www.ncbi.nlm.nih.gov/protein/NP_031401.1

  • Q: Why is this protein supplied with 0.4 M urea in the formulation buffer?

    A: Without the presence of urea, this protein would be insoluble. This is partially due to the expression system and the nature of the protein. Any attempt to dilute the urea down will cause the protein to precipitate.

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