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Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF

Catalog #: E-305
146 Citations 2 Reviews Datasheet / COA / SDS
Analyzed by SEC-MALS
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E-305-025

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Recombinant Human Ubiquitin‑activating Enzyme/UBE1 Protein SEC-MALS.
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Citations (146)
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Reviews (2)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF Summary

  • R&D Systems Sf 21 (baculovirus)-derived Recombinant Human Ubiquitin Activating Enzyme (UBE1) (E-305)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain
Activity
Recombinant Human Ubiquitin Activating Enzyme (UBE1) is a member of the Ubiquitin-activating (E1) enzyme family that is required for the first step of the enzymatic cascade that subsequently utilizes a Ubiquitin-conjugating (E2) enzyme and a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Ubiquitin Activating Enzyme (UBE1) concentration of 50-200 nM.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Ubiquitin-activating Enzyme/UBE1 protein
Accession #
P22314.3
Predicted Molecular Mass
118 kDa

Product Datasheets

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E-305

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

E-305

Formulation Supplied as a solution in HEPES, NaCl and TCEP.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Scientific Data

SEC-MALS View Larger

Recombinant Human Ubiquitin‑activating Enzyme/UBE1 Protein (Catalog # E-305) has a molecular weight (MW) of 112-124 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Ubiquitin-activating Enzyme/UBE1

Ubiquitin-activating Enzyme (UBE1), also known as Ubiquitin-like Modifier Activating Enzyme 1 (UBA1), is a 1058 amino acid (aa) canonical member of the Ubiquitin-activating (E1) enzyme family of proteins with a predicted molecular weight of 118 kDa.  It is ubiquitously expressed and highly conserved; mouse and rat UBE1 share 95% and 96% aa sequence identity with the human UBE1 protein, respectively. UBE1 is found in the cytoplasm and nucleus, and contains a conserved active-site cysteine residue and ATP-binding site common to E1 enzymes (1-3). UBE1 is responsible for the first step in Ubiquitin-protein isopeptide bond formation (4,5). Ubiquitin is activated by UBE1 and thereafter linked to the side chain of a cysteine residue in UBE1, Cys632 in humans, yielding a Ubiquitin-UBE1 conjugate via a thioester bond (5-8). The activated Ubiquitin is then transferred to a lysine residue on the target protein via the Ubiquitin-conjugating  – Ubiquitin ligase enzyme cascade. UBE1 is required for cell cycle progression and has been linked to cellular responses to DNA damage such as nucleotide excision repair (3,9,10). Mutations in UBE1 are associated with X-linked lethal infantile spinal muscular atrophy (11).  UBE1 is a critical component for the initiation of in vitro ubiquitin conjugation reactions.   

References
  1. Handley, P.M. et al. (1991) Proc. Natl. Acad. Sci. USA 88:258.
  2. Nagai, Y. et al. (1995) J. Cell Sci. 108:2145.
  3. Stephen, A.G. et al. (1996) J. Biol. Chem. 271:15608.
  4. Hershko, A. et al. (1983) J. Biol. Chem. 258:8206.
  5. Schulman, B.A. & J.W. Harper (2009) Nat. Rev. Mol. Cell Biol. 10:319.
  6. Haas, A.L. et al. (1982) J. Biol. Chem. 257:2543.
  7. Haas, A.L. & I.A. Rose (1982) J. Biol. Chem. 257:10329.
  8. Pickart, C.M. et al. (1994) J. Biol. Chem. 269:7115.
  9. Nouspikel, T. & P.C. Hanawalt (2006) Proc. Natl. Acad. Sci. USA 103:16188.
  10. Moundry, P. et al. (2012) Cell Cycle 11:1573.
  11. Ramser, J. et al. (2008) Am. J. Hum. Genet. 82:188.
Entrez Gene IDs
7317 (Human); 22201 (Mouse); 314432 (Rat); 100009225 (Rabbit); 853670 (Yeast)
Alternate Names
A1S9T and BN75 temperature sensitivity complementing; A1S9T; A1ST; AMCX1; GXP1; MGC4781; POC20 centriolar protein homolog; POC20; Protein A1S9; SMAX2; UBA1; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1A1S9; UBE1X; ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivitycomplementing); Ubiquitin-activating enzyme E1; Ubiquitinactivating Enzyme; Ubiquitin-activating Enzyme; ubiquitin-like modifier activating enzyme 1; ubiquitin-like modifier-activating enzyme 1

Citations for Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

146 Citations: Showing 1 - 10
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  1. Pupylation-based proximity labeling reveals APC/C-mediated ubiquitination and degradation of PEROXIN11C in soybean abiotic stress responses
    Authors: Zhang, Y;Yang, X;Chen, T;Su, K;Zhu, Y;Li, S;Xiang, F;Lu, Q;
    Cell reports
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  2. SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin
    Authors: Luo, S;He, Y;He, Y;Wang, D;
    Frontiers in cellular neuroscience
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  3. Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation
    Authors: Kolvenbach, A;Palumbieri, MD;Colby, T;Nadarajan, D;Bode, R;Mati?, I;
    Nature chemical biology
    Species: N/A
    Sample Types: Peptide, Protein, Recombinant Protein
    Applications: Bioassay
  4. Optimized isolation of enzymatically active ubiquitin E3 ligase E6AP/UBE3A from mammalian cells
    Authors: Schafer, JM;Muli, CS;Heikal, RA;Dyba, MA;Tarasov, SG;Stratton, MM;Strieter, ER;Walters, KJ;
    Protein expression and purification
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  5. The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
    Authors: Yao, Y;Hong, S;Yoshida, S;Swaroop, V;Curtin, B;Inoki, K;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. The RING-type E3 ligase RIE1 sustains leaf longevity by specifically targeting AtACS7 to fine-tune ethylene production in Arabidopsis
    Authors: Tang, X;Mei, Y;He, K;Liu, R;Lv, X;Zhao, Y;Li, W;Wang, Q;Gong, Q;Li, S;Xu, C;Zheng, X;Cao, Q;Wang, D;Wang, NN;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  7. Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation
    Authors: Kim, HS;Roche, B;Bhattacharjee, S;Todeschini, L;Chang, AY;Hammell, C;Verdel, A;Martienssen, RA;
    Nature communications
    Species: E. coli
    Sample Types: Protein
    Applications: Bioassay
  8. Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes
    Authors: Lu, J;Yu, J;Liu, P;Gu, J;Chen, Y;Zhang, T;Li, J;Wang, T;Yang, W;Lin, R;Wang, F;Qi, M;Li, T;Liu, Y;
    Cell reports
    Species: E. coli
    Sample Types: Recombinant Protein
    Applications: Bioassay
  9. Fine-tuning of IPA1 transactivation activity by E3 ligase IPI7-mediated non-proteolytic K29-ubiquitination during Magnaporthe oryzae infection
    Authors: Shi, H;Yin, J;Zhao, Z;Yu, H;Yi, H;Xu, L;Tong, H;He, M;Zhu, X;Lu, X;Xiong, Q;Li, W;Tang, Y;Hou, Q;Song, L;Wang, L;Chen, X;Sun, C;Li, T;Fan, J;Li, Y;Qin, P;Wang, WM;Li, S;Chen, X;Li, J;Wang, J;
    Nature communications
    Species: N/A
    Sample Types: Protein
    Applications: Bioassay
  10. The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function
    Authors: Zhang, R;Wu, Y;Qu, X;Yang, W;Wu, Q;Huang, L;Jiang, Q;Ma, J;Zhang, Y;Qi, P;Chen, G;Jiang, Y;Zheng, Y;Wang, X;Wei, Y;Xu, Q;
    Nature communications
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  11. FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions
    Authors: Alcón, P;Kaczmarczyk, AP;Ray, KK;Liolios, T;Guilbaud, G;Sijacki, T;Shen, Y;McLaughlin, SH;Sale, JE;Knipscheer, P;Rueda, DS;Passmore, LA;
    Nature
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  12. Bivalent target-binding bioPROTACs induce potent degradation of oncogenic SHP2
    Authors: Hoffman, M;Krum, D;Wittrup, KD;
    The Journal of biological chemistry
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  13. Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics
    Authors: Kubori, T;Arasaki, K;Oide, H;Kitao, T;Nagai, H;
    eLife
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  14. Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
    Authors: Radko-Juettner, S;Yue, H;Myers, JA;Carter, RD;Robertson, AN;Mittal, P;Zhu, Z;Hansen, BS;Donovan, KA;Hunkeler, M;Rosikiewicz, W;Wu, Z;McReynolds, MG;Roy Burman, SS;Schmoker, AM;Mageed, N;Brown, SA;Mobley, RJ;Partridge, JF;Stewart, EA;Pruett-Miller, SM;Nabet, B;Peng, J;Gray, NS;Fischer, ES;Roberts, CWM;
    Nature
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  15. The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato
    Authors: Wu, S;Hu, C;Zhu, C;Fan, Y;Zhou, J;Xia, X;Shi, K;Zhou, Y;Foyer, CH;Yu, J;
    Molecular plant
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  16. The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
    Authors: Olazabal-Herrero, A;He, B;Kwon, Y;Gupta, AK;Dutta, A;Huang, Y;Boddu, P;Liang, Z;Liang, F;Teng, Y;Lan, L;Chen, X;Pei, H;Pillai, MM;Sung, P;Kupfer, GM;
    Cell reports
    Species: N/A
    Sample Types: DNA, Recombinant Protein, RNA
    Applications: Bioassay
  17. Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP
    Authors: Sabri, N;Cuneo, MJ;Marzahn, MR;Lee, J;Bouchard, JJ;Güllülü, Ö;Vaithiyalingam, S;Borgia, MB;Schmit, J;Mittag, T;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  18. Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
    Authors: Li, P;Zhen, Y;Kim, C;Liu, Z;Hao, J;Deng, H;Deng, H;Zhou, M;Wang, XD;Qin, T;Yu, Y;
    Science advances
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  19. Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions
    Authors: Xu, Y;Qu, M;He, Y;He, Q;Shen, T;Luo, J;Tan, D;Bao, H;Xu, C;Ji, X;Hu, X;Barkat, MQ;Zeng, LH;Wu, X;
    The Journal of biological chemistry
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  20. Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach
    Authors: VanDyke, D;Xu, L;Sargunas, PR;Gilbreth, RN;Baca, M;Gao, C;Hunt, J;Spangler, JB;
    The Journal of biological chemistry
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  21. UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean
    Authors: Sun, J;Huang, S;Lu, Q;Li, S;Zhao, S;Zheng, X;Zhou, Q;Zhang, W;Li, J;Wang, L;Zhang, K;Zheng, W;Feng, X;Liu, B;Kong, F;Xiang, F;
    Nature communications
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  22. E3 ubiquitin ligase TRIM21 targets TIF1? to regulate ?-catenin signaling in glioblastoma
    Authors: Li, Y;Bao, L;Zheng, H;Geng, M;Chen, T;Dai, X;Xiao, H;Yang, L;Mao, C;Qiu, Y;Xu, Y;Wang, D;Li, MX;Chen, Q;
    Theranostics
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  23. Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1
    Authors: Meyers, M;Cismoski, S;Panidapu, A;Chie-Leon, B;Nomura, DK;
    bioRxiv : the preprint server for biology
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  24. Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes
    Authors: Yan, W;Zhong, Y;Hu, X;Xu, T;Zhang, Y;Kales, S;Qu, Y;Talley, DC;Baljinnyam, B;LeClair, CA;Simeonov, A;Polster, BM;Huang, R;Ye, Y;Rai, G;Henderson, MJ;Tao, D;Fang, S;
    Nature communications
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  25. Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma
    Authors: Li, Y;Wang, H;Sun, B;Su, G;Cang, Y;Zhao, L;Zhao, S;Li, Y;Mao, B;Ma, P;
    Cell death & disease
    Species: N/A
    Sample Types: Protein
    Applications: Bioassay
  26. Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation
    Authors: Fang, Z;Li, X;Yoshino, Y;Suzuki, M;Qi, H;Murooka, H;Katakai, R;Shirota, M;Mai Pham, TA;Matsuzawa, A;Otsuka, K;Ishioka, C;Mori, T;Chiba, N;
    Cell reports
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  27. Identification of XAF1 as an endogenous AKT inhibitor
    Authors: Chen, M;Wang, K;Han, Y;Yan, S;Yuan, H;Liu, Q;Li, L;Li, N;Zhu, H;Lu, D;Wang, K;Liu, F;Luo, D;Zhang, Y;Jiang, J;Li, D;Zhang, L;Ji, H;Zhou, H;Chen, Y;Qin, J;Gao, D;
    Cell reports
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  28. PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9
    Authors: R Zhou, J Chen, Y Xu, Y Ye, G Zhong, T Chen, L Qiu
    Cell Death & Disease, 2023-04-08;14(4):258.
    Species: Human
    Sample Types:
    Applications: Bioassay
  29. DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation
    Authors: X Xu, CW Chang, M Li, K Omabe, N Le, YH Chen, F Liang, Y Liu
    Nature Communications, 2023-03-04;14(1):1233.
    Species: Human
    Sample Types: Protein
    Applications: Ubiquitination
  30. A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
    Authors: X Du, J Pang, B Gu, T Si, Y Chang, T Li, M Wu, Z Wang, Y Wang, J Feng, N Wu, J Man, H Li, A Li, T Zhang, B Wang, X Duan
    Nucleic Acids Research, 2023-02-22;0(0):.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  31. Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region
    Authors: M Gingerich, J Zhu, B Chai, M Vincent, N Xie, V Sidarala, N Kotov, D Sahu, D Klionsky, S Schnell, S Soleimanpo
    The Journal of Biological Chemistry, 2023-02-22;0(0):103057.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  32. TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
    Authors: TET Mevissen, AV Prasad, JC Walter
    Cell Reports, 2023-02-18;42(2):112125.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  33. Structural basis for clearing of ribosome collisions by the RQT complex
    Authors: K Best, K Ikeuchi, L Kater, D Best, J Musial, Y Matsuo, O Berninghau, T Becker, T Inada, R Beckmann
    Nature Communications, 2023-02-17;14(1):921.
    Species: N/A
    Sample Types: Protein Extracts
    Applications: Bioassay
  34. DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation
    Authors: X Xu, CW Chang, M Li, K Omabe, N Le, YH Chen, F Liang, Y Liu
    Nature Communications, 2023;14(1):1233.
    Species: Human
    Sample Types: Protein
    Applications: Ubiquitination
  35. MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening
    Authors: W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan
    Journal of advanced research, 2022-12-15;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  36. Regulation of Epstein-Barr Virus Minor Capsid Protein BORF1 by TRIM5alpha
    Authors: LT Lin, YS Lu, HH Huang, H Chen, SW Hsu, LK Chang
    International Journal of Molecular Sciences, 2022-12-05;23(23):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  37. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy
    Authors: TT Liu, H Yang, FF Zhuo, Z Yang, MM Zhao, Q Guo, Y Liu, D Liu, KW Zeng, PF Tu
    EBioMedicine, 2022-11-11;86(0):104353.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  38. Cooperative assembly of p97 complexes involved in replication termination
    Authors: OV Kochenova, S Mukkavalli, M Raman, JC Walter
    Nature Communications, 2022-11-03;13(1):6591.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  39. The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
    Authors: X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han
    Oncogenesis, 2022-07-20;11(1):40.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  40. Dipyridamole for tracking amyloidogenic proteins aggregation and enhancing polyubiquitination
    Authors: F Laneri, S García-Viñ, V Lanza, N Licciardel, D Milardi, S Sortino, G Grasso
    Archives of biochemistry and biophysics, 2022-07-19;728(0):109354.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  41. ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia
    Authors: L Lao, I Bourdeau, L Gagliardi, X He, W Shi, B Hao, M Tan, Y Hu, J Peng, B Coulombe, DJ Torpy, HS Scott, A Lacroix, H Luo, J Wu
    Nucleic Acids Research, 2022-06-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease
    Authors: SK Pirooznia, H Wang, N Panicker, M Kumar, S Neifert, MA Dar, E Lau, BG Kang, J Redding-Oc, JC Troncoso, VL Dawson, TM Dawson
    Science Advances, 2022-04-01;8(13):eabh1824.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  43. Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation
    Authors: Y Zhou, R Zheng, S Liu, C Disoma, A Du, S Li, Z Chen, Z Dong, Y Zhang, S Li, P Liu, A Razzaq, X Chen, Y Liao, S Tao, Y Liu, L Xu, Q Zhang, J Peng, X Deng, S Li, T Jiang, Z Xia
    The Journal of Biological Chemistry, 2022-01-13;0(0):101584.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  44. Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
    Authors: S Yoon, K Bogdanov, D Wallach
    Cell Death and Differentiation, 2022-01-09;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  45. Regulation of Epstein-Barr Virus Minor Capsid Protein BORF1 by TRIM5alpha
    Authors: LT Lin, YS Lu, HH Huang, H Chen, SW Hsu, LK Chang
    International Journal of Molecular Sciences, 2022;23(23):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  46. MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening
    Authors: W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan
    Journal of advanced research, 2022;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  47. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB
    Authors: M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur
    Cell Death and Differentiation, 2021-11-27;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  48. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
    Authors: T Mahlokozer, B Patel, H Chen, P Desouza, X Qu, DD Mao, D Hafez, W Yang, R Taiwo, M Paturu, A Salehi, AD Gujar, GP Dunn, N Mosammapar, AA Petti, H Yano, AH Kim
    Nature Communications, 2021-11-03;12(1):6321.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  49. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX
    Authors: RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra
    The Journal of Biological Chemistry, 2021-09-26;0(0):101253.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  50. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
    Authors: Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang, TY Wang, J Carriere, AC Savas, M Zarinfar, S Rice, H Yang, W Yuan, JA Camarero, J Yu, XS Chen, C Zhang, P Feng
    MBio, 2021-09-21;0(0):e0233521.
    Species: E. coli, Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  51. Structural basis of human transcription-DNA repair coupling
    Authors: G Kokic, FR Wagner, A Chernev, H Urlaub, P Cramer
    Nature, 2021-09-15;0(0):.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  52. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
    Authors: C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins
    Nature Communications, 2021-09-06;12(1):5263.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  53. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
    Authors: Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier
    Nature Communications, 2021-08-18;12(1):5010.
    Applications: Bioassay
  54. Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
    Authors: CW Davies, SE Vidal, L Phu, J Sudhamsu, TB Hinkle, S Chan Rosen, FR Schumacher, YJ Zeng, C Schwerdtfe, AS Peterson, JR Lill, CM Rose, AS Shaw, IE Wertz, DS Kirkpatric, JT Koerber
    Nature Communications, 2021-07-29;12(1):4608.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  55. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
    Authors: S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, P González-A, A Winkler, G Lund, T Purohit, E Kim, X Zhang, JM Ray, S He, C Nikolaidis, J Ndoj, J Wang, ? Jaremko, M Jaremko, RJH Ryan, ML Guzman, J Grembecka, T Cierpicki
    Nature Chemical Biology, 2021-06-21;17(7):784-793.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  56. A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein
    Authors: NM McCormack, MB Abera, ES Arnold, RM Gibbs, SE Martin, E Buehler, YC Chen, L Chen, KH Fischbeck, BG Burnett
    Cell Reports, 2021-05-11;35(6):109125.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  57. CRL4AMBRA1 is a master regulator of D-type cyclins
    Authors: D Simoneschi, G Rona, N Zhou, YT Jeong, S Jiang, G Milletti, AA Arbini, A O'Sullivan, AA Wang, S Nithikasem, S Keegan, Y Siu, V Cianfanell, E Maiani, F Nazio, F Cecconi, F Boccalatte, D Fenyö, DR Jones, L Busino, M Pagano
    Nature, 2021-04-14;592(7856):789-793.
    Species: Human
    Sample Types: Peptide
    Applications: Bioassay
  58. BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract
    Authors: JK Barrows, G Fullbright, DT Long
    Nucleic Acids Research, 2021-04-06;0(0):.
    Species: N/A
    Sample Types: Plasmid
    Applications: Ubiquitination
  59. DAZAP2 acts as specifier of the p53 response to DNA damage
    Authors: MC Liebl, J Moehlenbri, H Becker, G Raddatz, SK Abdeen, RI Aqeilan, F Lyko, TG Hofmann
    Nucleic Acids Research, 2021-03-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  60. CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis
    Authors: D Huang, Q Li, X Sun, X Sun, Y Tang, Y Qu, D Liu, T Yu, G Li, T Tong, Y Zhang
    Cell Death and Differentiation, 2020-12-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis
    Authors: XY Lu, XJ Shi, A Hu, JQ Wang, Y Ding, W Jiang, M Sun, X Zhao, J Luo, W Qi, BL Song
    Nature, 2020-11-11;0(0):.
    Species: Complex Species Category
    Sample Types: Complex Sample Type
    Applications: Bioassay
  62. CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
    Authors: MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar
    Cell Death & Disease, 2020-09-10;11(9):740.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitylation
  63. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
    Authors: M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer
    Cell Rep, 2020-08-04;32(5):107985.
    Species: Human
    Sample Types: Portein, Recombinant Protein
    Applications: Bioassay
  64. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
    Authors: M S?abicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, KA Donovan, QL Sievers, J Koeppel, D Suchyta, AS Sperling, EC Fink, JA Gasser, LR Wang, SM Corsello, RS Sellar, M Jan, D Gillingham, C Scholl, S Fröhling, TR Golub, ES Fischer, NH Thomä, BL Ebert
    Nature, 2020-06-03;0(0):.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  65. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex
    Authors: ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai
    Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322.
    Species: Spodoptera frugiperda
    Sample Types: Whole Cells
    Applications: Ubiquitination
  66. Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis
    Authors: YS Yoo, YJ Park, HS Lee, NTK Oanh, MY Cho, J Heo, ES Lee, H Cho, YY Park, H Cho
    Cell Death Dis, 2019-12-09;10(12):938.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  67. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
    Authors: TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan
    Cell Rep, 2019-11-05;29(6):1499-1510.e6.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  68. Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response
    Authors: J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur
    Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562.
    Species: Virus - HPV
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  69. The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for maintaining�DNA methylation
    Authors: RM Vaughan, SB Rothbart, BM Dickson
    J. Biol. Chem., 2019-09-03;0(0):.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: Bioassay
  70. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development
    Authors: P Wang, F Yan, Z Li, Y Yu, SE Parnell, Y Xiong
    J. Clin. Invest., 2019-07-25;130(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  71. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning
    Authors: P Ma, NN Song, Y Li, Q Zhang, L Zhang, L Zhang, Q Kong, L Ma, X Yang, B Ren, C Li, X Zhao, Y Li, Y Xu, X Gao, YQ Ding, B Mao
    Cell Rep, 2019-07-09;28(2):541-553.e4.
    Applications: Bioassay
  72. DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
    Authors: F Liang, AS Miller, S Longerich, C Tang, D Maranon, EA Williamson, R Hromas, C Wiese, GM Kupfer, P Sung
    Nat Commun, 2019-06-28;10(1):2849.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  73. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains
    Authors: M Di Rienzo, M Antonioli, C Fusco, Y Liu, M Mari, I Orhon, G Refolo, F Germani, M Corazzari, A Romagnoli, F Ciccosanti, B Mandriani, MT Pellico, R De La Torr, H Ding, M Dentice, M Neri, A Ferlini, F Reggiori, M Kulesz-Mar, M Piacentini, G Merla, GM Fimia
    Sci Adv, 2019-05-08;5(5):eaau8857.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  74. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
    Authors: Q Yin, T Han, B Fang, G Zhang, C Zhang, ER Roberts, V Izumi, M Zheng, S Jiang, X Yin, M Kim, J Cai, EB Haura, JM Koomen, KSM Smalley, L Wan
    Nat Commun, 2019-04-23;10(1):1870.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  75. Mechanism for recycling tRNAs on stalled ribosomes
    Authors: MCJ Yip, AFA Keszei, Q Feng, V Chu, MJ McKenna, S Shao
    Nat. Struct. Mol. Biol., 2019-04-22;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  76. Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
    Authors: G Lu, J Yi, A Gubas, YT Wang, Y Wu, Y Ren, M Wu, Y Shi, C Ouyang, HWS Tan, T Wang, L Wang, ND Yang, S Deng, D Xia, RH Chen, SA Tooze, HM Shen
    Autophagy, 2019-03-30;0(0):1-18.
    Applications: Bioassay
  77. Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination
    Authors: Z Liang, F Liang, Y Teng, X Chen, J Liu, S Longerich, T Rao, AM Green, NB Collins, Y Xiong, L Lan, P Sung, GM Kupfer
    Cell Rep, 2019-01-15;26(3):564-572.e5.
    Applications: Bioassay
  78. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner
    Authors: B Liu, J Yi, X Yang, L Liu, X Lou, Z Zhang, H Qi, Z Wang, J Zou, WG Zhu, W Gu, J Luo
    Oncogene, 2018-12-07;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  79. Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
    Authors: Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao
    Nature, 2018-11-12;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  80. The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPAR?
    Authors: JM Lee, SS Choi, YH Lee, KW Khim, S Yoon, BG Kim, D Nam, PG Suh, K Myung, JH Choi
    Exp. Mol. Med., 2018-10-15;50(10):135.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  81. XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation
    Authors: X Huang, XN Wang, XD Yuan, WY Wu, PE Lobie, Z Wu
    Oncogene, 2018-10-01;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  82. SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
    Authors: ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai
    Nat. Chem. Biol., 2018-09-06;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  83. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation
    Authors: F Lampert, D Stafa, A Goga, MV Soste, S Gilberto, N Olieric, P Picotti, M Stoffel, M Peter
    Elife, 2018-06-18;7(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  84. Chromatin assembly factor-1 (CAF-1) chaperone regulates Cse4 deposition into chromatin in budding yeast
    Authors: GS Hewawasam, K Dhatchinam, M Mattingly, C Seidel, JL Gerton
    Nucleic Acids Res., 2018-05-18;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  85. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins
    Authors: R Khanna, V Krishnamoo, VK Parnaik
    FEBS J., 2018-05-03;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  86. CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells
    Authors: S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura
    Oncotarget, 2018-04-03;9(25):17645-17655.
    Applications: Bioassay
  87. Post-translational modification of OCT4 in breast cancer tumorigenesis
    Authors: Y Cho, HG Kang, SJ Kim, S Lee, S Jee, SG Ahn, MJ Kang, JS Song, JY Chung, EC Yi, KH Chun
    Cell Death Differ., 2018-03-06;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  88. The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation
    Authors: X Chen, Z He, M Fu, Y Wang, H Wu, X Li, H Cao, SJ Zheng
    J. Virol., 2018-02-26;0(0):.
    Applications: Bioassay
  89. HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer
    Authors: SY Kim, HJ Kim, HJ Kim, DH Kim, CH Kim, JH Han, HK Byeon, K Lee
    Autophagy, 2018-02-21;0(0):1-89.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  90. PI5P4K? functions in DTX1-mediated Notch signaling
    Authors: L Zheng, SD Conner
    Proc. Natl. Acad. Sci. U.S.A., 2018-02-12;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  91. Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7
    Authors: M Higa, K Tanaka, M Saijo
    FEBS J., 2018-01-25;0(0):.
    Applications: Bioassay
  92. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair
    Authors: JR Brickner, JM Soll, PM Lombardi, CB Vågbø, MC Mudge, C Oyeniran, R Rabe, J Jackson, ME Sullender, E Blazosky, AK Byrum, Y Zhao, MA Corbett, J Gécz, M Field, A Vindigni, G Slupphaug, C Wolberger, N Mosammapar
    Nature, 2017-11-08;551(7680):389-393.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  93. CHIP as a membrane-shuttling proteostasis sensor
    Authors: Y Kopp, WH Lang, TB Schuster, A Martínez-L, HF Hofbauer, R Ernst, G Calloni, RM Vabulas
    Elife, 2017-11-01;6(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  94. COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation
    Authors: N Lian, X Liu, X Wang, Y Zhou, H Li, J Li, T Mao
    Proc. Natl. Acad. Sci. U.S.A., 2017-10-30;114(46):12321-12326.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  95. BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance
    Authors: B Zhang, M Holmlund, S Lorrain, M Norberg, L Bakó, C Fankhauser, O Nilsson
    Elife, 2017-08-22;6(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  96. Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
    Authors: H Janouskova, G El Tekle, E Bellini, ND Udeshi, A Rinaldi, A Ulbricht, T Bernasocch, G Civenni, M Losa, T Svinkina, CM Bielski, GV Kryukov, L Cascione, S Napoli, RI Enchev, DG Mutch, ME Carney, A Berchuck, BJN Winterhoff, RR Broaddus, P Schraml, H Moch, F Bertoni, CV Catapano, M Peter, SA Carr, LA Garraway, PJ Wild, JP Theurillat
    Nat. Med., 2017-08-14;23(9):1046-1054.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  97. Ubiquitin-dependent regulation of Cdc42 by XIAP
    Authors: A Murali, J Shin, H Yurugi, A Krishnan, M Akutsu, A Carpy, B Macek, K Rajalingam
    Cell Death Dis, 2017-06-29;8(6):e2900.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  98. BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation
    Authors: A Bononi, C Giorgi, S Patergnani, D Larson, K Verbruggen, M Tanji, L Pellegrini, V Signorato, F Olivetto, S Pastorino, M Nasu, A Napolitano, G Gaudino, P Morris, G Sakamoto, LK Ferris, A Danese, A Raimondi, C Tacchetti, S Kuchay, HI Pass, EB Affar, H Yang, P Pinton, M Carbone
    Nature, 2017-06-14;546(7659):549-553.
    Applications: Bioassay
  99. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response
    Authors: ZQ Fan, JY Chen, JF Kuang, WJ Lu, W Shan
    Front Plant Sci, 2017-06-12;8(0):995.
    Applications: Bioassay
  100. RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
    Authors: S Inano, K Sato, Y Katsuki, W Kobayashi, H Tanaka, K Nakajima, S Nakada, H Miyoshi, K Knies, A Takaori-Ko, D Schindler, M Ishiai, H Kurumizaka, M Takata
    Mol. Cell, 2017-06-01;66(5):622-634.e8.
    Species: Human
    Sample Types: Protein
    Applications: Enzyme Assay
  101. CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag
    Authors: H Takeda, W Zhou, K Kido, R Suno, T Iwasaki, T Kobayashi, T Sawasaki
    PLoS ONE, 2017-05-25;12(5):e0178246.
    Applications: Enzyme Assay
  102. DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues
    Authors: V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez
    Cell Death Dis, 2017-05-25;8(5):e2816.
    Species: Bacteria - E. Coli, Human
    Sample Types: Protein, Recombinant Protein
    Applications: Bioassay
  103. Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster
    Authors: S Schunter, R Villa, V Flynn, JB Heidelberg, AK Classen, P Beli, PB Becker
    PLoS ONE, 2017-05-16;12(5):e0177408.
    Species: Worm - Spodoptera frugiperda (Fall Army Worm)
    Sample Types: Protein
    Applications: Bioassay
  104. Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlying photomorphogenic development in Arabidopsis
    Authors: X Xu, PK Kathare, VN Pham, Q Bu, A Nguyen, E Huq
    Development, 2017-04-18;0(0):.
    Applications: Bioassay
  105. Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation
    Authors: X Wei, X Wang, J Zhan, Y Chen, W Fang, L Zhang, H Zhang
    J. Cell Biol., 2017-04-13;0(0):.
    Applications: Bioassay
  106. Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis Thaliana By Promoting Nuclear Proteasome-Mediated HY5 Degradation
    Authors: C Perea-Resa, MA Rodríguez-, E Iniesto, V Rubio, J Salinas
    Mol Plant, 2017-04-12;0(0):.
    Applications: Bioassay
  107. Tissue-specific Ubiquitination by IPA1 INTERACTING PROTEIN 1 Modulates IPA1 Protein Levels to Regulate Plant Architecture in Rice
    Authors: J Wang, H Yu, G Xiong, Z Lu, Y Jiao, X Meng, G Liu, X Chen, Y Wang, J Li
    Plant Cell, 2017-03-14;0(0):.
    Applications: Bioassay
  108. Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity
    Nucleic Acids Res., 2017-02-28;0(0):.
    Applications: Bioassay
  109. C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPAR?
    Authors: JH Kim, S Shin, J Seo, EW Lee, M Jeong, MS Lee, HJ Han, J Song
    Sci Rep, 2017-01-06;7(0):40023.
    Species: Human, Mouse
    Sample Types: Cell Lysates
    Applications: Ubiquitination
  110. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
    Authors: Xueting Lang
    J. Exp. Med, 2016-12-28;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  111. UBE3B is a Calmodulin-Regulated, Mitochondria-Associated E3 Ubiquitin Ligase
    Authors: Andrea Braganza
    J. Biol. Chem, 2016-12-21;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  112. Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution
    Authors: Ekta Tripathi
    EMBO J, 2016-12-19;0(0):.
    Applications: Bioassay
  113. Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation
    Authors: Francesca Nazio
    J. Cell Biol, 2016-12-08;215(6):841-856.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  114. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
    Oncogene, 2016-11-21;0(0):.
    Applications: Bioassay
  115. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53
    PLoS Biol., 2016-11-16;14(11):e2000733.
    Applications: Bioassay
  116. Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation
    Authors: Lin Mei
    Neuron, 2016-11-10;92(5):1007-1019.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  117. Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress
    Sci Rep, 2016-11-04;6(0):36171.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  118. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
    Elife, 2016-10-05;5(0):.
    Applications: Bioassay
  119. Identification and Characterization of MCM3 as a Novel KEAP1 Substrate
    J Biol Chem, 2016-09-12;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Ubiquitination
  120. The San1 ubiquitin ligase functions preferentially with ubiquitin-conjugating enzyme Ubc1 during protein quality control
    J Biol Chem, 2016-07-12;0(0):.
    Applications: Bioassay
  121. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase
    Authors: Mary E Matyskiela
    Nature, 2016-06-22;0(0):.
    Applications: Bioassay
  122. 14-3-3? loss leads to activation of the epithelial to mesenchymal transition due to the stabilization of c-Jun
    Authors: Kumarkrishna Raychaudhu
    J Biol Chem, 2016-06-03;0(0):.
    Applications: Bioassay
  123. hnRNP E1 Protects Chromosomal Integrity by Translational Regulation of Cdc27
    Authors: LA Link, BV Howley, GS Hussey, PH Howe
    Mol Cancer Res, 2016-04-21;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  124. Ubiquitination independent of E1 and E2 enzymes by bacterial effectors
    Authors: J Qiu, MJ Sheedlo, K Yu, Y Tan, ES Nakayasu, C Das, X Liu, ZQ Luo
    Nature, 2016-04-06;533(7601):120-4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice
    Authors: H Zhang, H Liu, Y Chen, X Yang, P Wang, T Liu, M Deng, B Qin, C Correia, S Lee, J Kim, M Sparks, AA Nair, DL Evans, KR Kalari, P Zhang, L Wang, Z You, SH Kaufmann, Z Lou, H Pei
    Nat Commun, 2016-01-05;7(0):10201.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  126. Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death.
    Authors: Kim C, Yun N, Lee J, Youdim M, Ju C, Kim W, Han P, Oh Y
    Cell Death Differ, 2015-07-24;23(2):333-46.
    Applications: Enzyme Assay
  127. Deltex1 antagonizes HIF-1alpha and sustains the stability of regulatory T cells in vivo.
    Authors: Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, Jiang S, Lai M
    Nat Commun, 2015-02-19;6(0):6353.
    Applications: Bioassay
  128. Tumour suppressor TRIM33 targets nuclear beta-catenin degradation.
    Authors: Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S
    Nat Commun, 2015-02-02;6(0):6156.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  129. Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
    Authors: Rout, Manoj K, Hodge, Curtis D, Markin, Craig J, Xu, Xin, Glover, J N Mark, Xiao, Wei, Spyracopoulos, Leo
    J Am Chem Soc, 2014-12-05;136(50):17446-58.
    Applications: Bioassay
  130. Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
    Authors: Yue, Shen, Tang, Liu-Ya, Tang, Ying, Tang, Yi, Shen, Qiu-Hong, Ding, Jie, Chen, Yan, Zhang, Zengdi, Yu, Ting-Tin, Zhang, Ying E, Cheng, Steven Y
    Elife, 2014-06-12;3(0):.
    Applications: Bioassay
  131. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.
    Authors: Kumar, Ravindra, Whitehurst, Christop, Pagano, Joseph S
    J Virol, 2014-03-26;88(11):6411-22.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  132. The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
    Authors: Townley-Tilson, W H Davi, Wu, Yaxu, Ferguson, James E, Patterson, Cam
    PLoS ONE, 2014-02-21;9(2):e89451.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  133. A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.
    Authors: Hornburger M, Mayer B, Leonhardt S, Willer E, Zahler S, Beyerle A, Rajalingam K, Vollmar A, Furst R
    FASEB J, 2013-12-26;28(4):1938-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  134. Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance.
    Authors: Lonskaya I, Desforges N, Hebron M, Moussa C
    PLoS ONE, 2013-12-26;8(12):e83914.
    Applications: Enzyme Assay
  135. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.
    Authors: Liu, Weixiao, Shang, Yonglian, Zeng, Yan, Liu, Chao, Li, Yanchang, Zhai, Linhui, Wang, Pan, Lou, Jizhong, Xu, Ping, Ye, Yihong, Li, Wei
    EMBO J, 2013-12-23;33(1):46-61.
    Applications: Bioassay
  136. Suppression of PPARgamma through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.
    Authors: Kim J, Park K, Lee E, Jang W, Seo J, Shin S, Hwang K, Song J
    Cell Death Differ, 2013-12-13;21(4):594-603.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Enzyme Assay
  137. Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation.
    Authors: Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E
    Oncogene, 2013-04-01;33(11):1438-47.
    Applications: Bioassay
  138. C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog.
    Authors: Lee, Hyojin, Alpi, Arno F, Park, Mi So, Rose, Ann, Koo, Hyeon-So
    PLoS ONE, 2013-03-28;8(3):e60071.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Enzyme Assay
  139. A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
    Authors: Singer, Alexande, Schulze, Sebastia, Skarina, Tatiana, Xu, Xiaohui, Cui, Hong, Eschen-Lippold, Lennart, Egler, Monique, Srikumar, Tharan, Raught, Brian, Lee, Justin, Scheel, Dierk, Savchenko, Alexei, Bonas, Ulla
    PLoS Pathog, 2013-01-24;9(1):e1003121.
    Applications: Bioassay
  140. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.
    Authors: Stanley D, Bartholomeeusen K, Crosby D, Kim D, Kwon E, Yen L, Cartozo N, Li M, Jager S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan N, Harris R, Peterlin B, Gross J
    PLoS Pathog, 2012-12-27;8(12):e1003085.
    Applications: Bioassay
  141. Structural determinants of ubiquitin conjugation in Entamoeba histolytica.
    Authors: Bosch D, Siderovski D
    J Biol Chem, 2012-12-03;288(4):2290-302.
    Species: Amoeba - Entamoeba histolytica
    Sample Types: Recombinant Protein
    Applications: Bioassay
  142. Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair.
    Authors: Lee, T-H, Park, J-M, Leem, S-H, Kang, T-H
    Oncogene, 2012-11-26;33(1):19-25.
    Applications: Bioassay
  143. A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.
    Authors: Wang, Jingya, Muntean, Andrew G, Wu, Laura, Hess, Jay L
    J Biol Chem, 2012-11-05;287(52):43410-6.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  144. Characterization of ML-IAP protein stability and physiological role in vivo.
    Authors: Varfolomeev, Eugene, Moradi, Elham, Dynek, Jasmin N, Zha, Jiping, Fedorova, Anna V, Deshayes, Kurt, Fairbrother, Wayne J, Newton, Kim, Le Couter, Jennifer, Vucic, Domagoj
    Biochem J, 2012-11-01;447(3):427-36.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  145. DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation.
    Authors: Pelisch F, Pozzi B, Risso G, Munoz M, Srebrow A
    J Biol Chem, 2012-07-23;287(36):30789-99.
    Applications: Bioassay
  146. TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.
    Authors: Bell JL, Malyukova A, Holien JK
    PLoS ONE, 2012-05-21;7(5):e37470.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay

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Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF
By Anonymous on 10/20/2017
Application: Enzymatic activity in vitro
Enzymatic activity in vitro Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF E-305
Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF
By Anonymous on 08/17/2016
Application: Enzymatic activity in vitro
Enzymatic activity in vitro Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF E-305