Recombinant Mouse Activin RIB/ALK-4 Fc Chimera Protein, CF Summary
|Mouse Activin RIB |
(Leu32 - Glu126)
(Pro100 - Lys330)
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: Activin RIB/ALK-4
Activin RIB, also known as ALK-4, is a glycosylated 58 kDa type I transmembrane receptor that belongs to the superfamily of TGF-beta serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules (1). These ligands bind to Activin RIIB which then associates with, and phosphorylates, the cytoplasmic domain of Activin RIB to initiate signal transduction (2, 3). Mature mouse Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain (4). Within the ECD, mouse Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB, respectively. It shares 23% - 38% aa sequence identity with other mouse type I receptors Activin RIA, BMPR-IA, BMPR-IB, and TGF-beta RI. Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein (5 - 7). Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan (8). Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation, apoptosis, and tumorigenesis (1, 9, 10).
- Chen, Y.-G. et al. (2006) Exp. Biol. Med. 231:534.
- Attisano, L. et al. (1996) Mol. Cell. Biol. 16:1066.
- Tsuchida, K. et al. (1995) Endocrinology 136:5493.
- Ebner, R. et al. (1993) Science 260:1344.
- Chapman, S.C. and T.K. Woodruff (2001) Mol. Endocrinol. 15:668.
- Bianco, C. et al. (2002) Mol. Cell. Biol. 22:2586.
- Gray, P.C. et al. (2003) Proc. Natl. Acad. Sci. 100:5193.
- Lewis, K.A. et al. (2000) Nature 404:411.
- Gu, Z. et al. (1998) Genes Dev. 12:844.
- Chen, Y. et al. (2004) Dev. Biol. 268:280.
Citation for Recombinant Mouse Activin RIB/ALK-4 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
ALK1 signaling regulates early postnatal lymphatic vessel development.
Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
Sample Types: N/A
Applications: ELISA (Standard)
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