Recombinant Mouse ADAMTS1 Protein, CF
Recombinant Mouse ADAMTS1 Protein, CF Summary
Phe254-Cys725, with a C-terminal 10-His tag
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1), also known as METH1, is the founding member of the family of secreted zinc proteases with a multidomain structure (1-3). The protein precursor consists of a signal peptide and the following domains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich, spacer and a variable number of thrombospondin type 1 motifs. Based on their substrate specificity, ADAMTS1 and associated family members may be key enzymes in the degradation of cartilage leading to inflammation and arthritis (4). It is an active protease cleaving alpha 2macroglobulin (5), aggrecan (6), and versican (7). Compared to ADAMTS4 (aggrecanase 1) and ADAMTS5 (aggrecanase 2), the aggrecanase activity of ADAMTS1 is lower. However, its activity can be enhanced by the binding of a cofactor such as fibulin1 (8). ADAMTS1 is essential for normal growth and the structure and function of the kidneys, adrenal glands and female reproductive organs (9). It also plays an important role in atherosclerosis (10). It has been shown to inhibit endothelial cell proliferation by direct binding and sequestration of VEGF165 and to inhibit fibroblast migration at high concentrations by binding to FGF 2 (11, 12). The purified rmADAMTS1 starts at the N terminus of the catalytic domain and ends in the Cys-rich domain.
- Vazquez, F. et al. (1999) J. Biol. Chem. 274:23349.
- Kuno, K. et al. (1997) J. Biol. Chem. 272:556.
- Porter, S. et al. (2005) Biochem. J. 386:15.
- Nagase, H. and M. Kashiwagi (2003) Arthritis Res. Ther. 5:94.
- Kuno, K. et al. (1999) J. Biol. Chem. 274:18821.
- Kuno, K. et al. (2000) FEBS Lett. 478:241.
- Russel, D. L. et al. (2003) J. Biol. Chem. 278:42330.
- Lee, N. et al. (2005) J. Biol. Chem. 280:34796.
- Shindo, T. et al. (2000) J. Clin. Invest. 105:1345.
- Wight, T.N. (2005) Arterioscler Thromb. Vasc. Biol. 25:12.
- Luque, A. et al. (2003) J. Biol. Chem. 278:23656.
- Krampert, M. et al. (2005) J. Biol. Chem. 280:23844.
Citations for Recombinant Mouse ADAMTS1 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
Filter your results:
A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo.
Authors: Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B
Sci Signal, 2016;9(451):ra103.
Sample Types: Whole Cells
Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome.
Authors: Hellbach N, Weise S, Vezzali R, Wahane S, Heidrich S, Roidl D, Pruszak J, Esser J, Vogel T
Hum Mol Genet, 2014;23(23):6177-90.
Sample Types: Whole Cells
Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1.
Authors: Lee YJ, Koch M, Karl D
Cancer Res., 2010;70(3):948-56.
Sample Types: Tissue Homogenates
No product specific FAQs exist for this product, however you mayView all Proteins and Enzyme FAQs
Protein Purification Kits
Reviews for Recombinant Mouse ADAMTS1 Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Mouse ADAMTS1 Protein, CF and earn rewards!
Have you used Recombinant Mouse ADAMTS1 Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image