Recombinant Mouse Angiopoietin-like Protein 2/ANGPTL2, CF Summary
|Mouse ANGPTL2 |
Accession # AAD55358
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: Angiopoietin-like Protein 2/ANGPTL2
Angiopoietin-like Protein 2 (ANGPTL2), also known as ARP2 is a secreted 56 kDa glycoprotein that contains a N-terminal coiled coil domain and a C-terminal fibrinogen like domain (1). ANGPTL2 is one of the seven members of the Angiopoietin Like family proteins, which are structurally similar to angiopoietins (2). Within mature mouse ANGPTL2, amino acid 260-493 contains the C-terminal fibrinogen like domain, and this domain shares 99% and 100% sequence identity with human and rat homologs, respectively. ANGPTL2 is widely expressed in many tissues, and its expression is induced by chronic, but not acute hypoxia (3). Elevated level of ANGPTL2 in the serum is also correlated with inflammation and obesity (3). ANGPTL2 has both pro and anti-angiogenic functions (1, 4). It serves as tumor suppressor in ovarian cancer (5), and also promote metastasis in various cancer types, making it potential biomarker for tumor progression (6-7). ANGPTL2 also function as growth factor to enhance the survival of hematopoietic progenitors, mediated by its coiled coil domain (8). Receptor of ANGPTL2 is recently identified as LILRB2, and both the coiled coil domain and fibrinogen like domain are required for optimal binding (9).
- Kim, I. et al. (1999) J Biol Chem 274:26523.
- Santulli, G. et al. (2014) Front Endocrinol 5:4.
- Tabata, M. et al. (2009) Cell Metab 10:178.
- Kubota, Y. et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102:13502.
- Kikuchi, R. et al. (2008) Cancer Res 68:5067.
- Odagiri, H. et al. (2014) Sci Signal 7:ra7.
- Endo, M. et al. (2012) Cancer Res 72:1784.
- Broxmeyer, H.E. et al. (2012) Blood Cells Mol Dis 48:25.
- Deng, M. et al. (2014) blood 124:924.
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