Recombinant Mouse ANGPTL8/Betatrophin Fc Chimera Protein, CF Summary
Accession # Q8R1L8
When Recombinant Mouse Angiopoietin-like 3 (Catalog # 9899-AN) is immobilized at 1 µg/mL, Recombinant Mouse Betatrophin Fc Chimera (Catalog # 9983-AN)binds with an ED50 of 0.12‑0.72 μg/mL.
2 μg/lane of Recombinant Mouse Angiopoietin-like Protein 8/Betatrophin was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 52-56 kDa and 105-110 kDa, respectively.
Background: Angiopoietin-like Protein 8/Betatrophin
Betatrophin (also called ANGPTL8, lipasin and RIPL), a novel secretory protein from liver and fatty tissues, is believed to be involved in lipid and glucose metabolism. It is most homologous to ANGPTL3 but lacks the fibrinogen-like domain of ANGPTL3 and other ANGPTL family members (1). Mouse Betatrophin is 183 amino acids (aa) in length and shares 72% aa identity with human Betatrophin. Betatrophin is a crucial modulator in lipid metabolism. It can form a complex with the N-terminal of ANGPTL3, and the complex is necessary for inhibition of LPL and triglyceride modulation (2). Betatrophin did not control beta-cell expansion in the mouse model (3). In addition to the lipid and glucose metabolism, ANGPTL8 has been reported to be involved in many other disorders (4).
- Quagliarini, F. et al. (2012) PNAS 109(48):19751.
- Chi, X., et al. (2017) Molecular Metabolism 6:1137.
- Cox A.R. et al. PLoS One (2016) 11:e0159276.
- Luo, M. et al. (2018) Front Endocrino 9:169.
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