Recombinant Mouse CL-K1/COLEC11 Protein, CF

Catalog # Availability Size / Price Qty
4687-CL-050
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Recombinant Mouse CL-K1/COLEC11 Protein, CF Summary

Purity
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to bind alpha -L-Fucose. Keshi, H. et al. (2006) Microbiol. Immunol. 50(12):1001.
Source
Mouse myeloma cell line, NS0-derived mouse CL-K1/COLEC11 protein
Gln27-Leu272, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Analysis
No results obtained: Gln27 predicted
Predicted Molecular Mass
27 kDa
SDS-PAGE
33-38 kDa, reducing conditions

Product Datasheets

4687-CL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: CL-K1/COLEC11

Collectins constitute a family of C-type lectins that recognize molecular patterns expressed on pathogens. Members of this glycoprotein family contain a N-terminal domain, a collagen-like domain, a neck region, and a C-terminal carbohydrate recognition domain (CRD). Collectins are typically secreted molecules, although CL-P1 is membrane bound and CL-L1 is found in the cytoplasm (1 - 3). Collectin kidney 1 (CL-K1), also known as collectin subfamily member 11 (COLEC11), is a 37 kDa collectin that circulates in the serum (4, 5). It associates into disulfide-linked oligomers and preferentially interacts with fucose residues in a calcium-dependent manner (4). Mature mouse CL-K1 shares 94% and 98% amino acid sequence identity with human and rat CL-K1, respectively. Within the CRD, mouse CL-K1 shares 52% aa sequence identity with CL-L1 and 23% - 32% aa sequence identity with collectins CL-P1, MBL, SP-A, and SP-D.

References
  1. Gupta, G. and A. Surolia (2007) Bioessays 29:452.
  2. van de Wetering, J.K. et al. (2004) Eur. J. Biochem. 271:1229.
  3. Holmskov, U. et al. (2003) Annu. Rev. Immunol. 21:547.
  4. Keshi, H. et al. (2006) Microbiol. Immunol. 50:1001.
  5. Accession # NP_082142.
Long Name
Collectin Kidney 1
Entrez Gene IDs
78989 (Human); 71693 (Mouse)
Alternate Names
CLK1; CL-K1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; COLEC11; collectin kidney I; Collectin kidney protein 1; collectin sub-family member 11; collectin-11; DKFZp686N1868; MGC3279

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