Recombinant Mouse IFN-alpha A Protein 12100-1: R&D Systems

Recombinant Mouse IFN-alpha A Protein

(17 citations)   
12100-1
 
Stability & Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: IFN-alpha
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
  • Long Name:
    Interferon alpha
  • Entrez Gene IDs:
    3440 (Human)
  • Alternate Names:
    IFNalpha; IFN-alpha
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

17 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Cell Lysates
    Application: Bioassay
  2. Network pharmacology of JAK inhibitors
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells
    Authors: P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi
    Oncogene, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence
    PLoS ONE, 2016;11(5):e0155947.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  5. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015;195(9):4446-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.
    Authors: Kuriakose T, Tripp R, Watford W
    PLoS Pathog, 2015;11(8):e1005038.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Corepressor Rcor1 is essential for murine erythropoiesis.
    Authors: Yao H, Goldman D, Nechiporuk T, Kawane S, McWeeney S, Tyner J, Fan G, Kerenyi M, Orkin S, Fleming W, Mandel G
    Blood, 2014;123(20):3175-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
    Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
    Proc Natl Acad Sci U S A, 2014;111(8):3068-73.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.
    Authors: Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q
    Mol Cancer, 2014;13(0):132.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
    Authors: Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P
    J Leukoc Biol, 2014;96(1):123-31.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. A role for the ITAM signaling module in specifying cytokine-receptor functions.
    Authors: Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R
    Nat Immunol, 2014;15(4):333-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. The exonuclease Trex1 restrains macrophage proinflammatory activation.
    Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
    J Immunol, 2013;191(12):6128-35.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
    Authors: Kerenyi, Marc A, Shao, Zhen, Hsu, Yu-Jung, Guo, Guoji, Luc, Sidinh, O'Brien, Kassandr, Fujiwara, Yuko, Peng, Cong, Nguyen, Minh, Orkin, Stuart H
    Elife, 2013;2(0):e00633.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
    Authors: Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R
    Biochem. Biophys. Res. Commun., 2009;379(4):964-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008;118(5):1680-90.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
    Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
    J. Virol., 2005;79(20):12828-39.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 17 Citations

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