Recombinant Mouse IGSF9 Protein, CF

R&D Systems | Catalog # 9140-S9

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Key Product Details

  • R&D Systems NS0-derived Recombinant Mouse IGSF9 Protein (9140-S9)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

NS0

Accession Number

Q05BQ1

Applications

Bioactivity
View all IGSF9 Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived mouse IGSF9 protein
Arg21-Leu730, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Arg21

Predicted Molecular Mass

78 kDa

SDS-PAGE

95-110 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation, and Storage

9140-S9
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IGSF9

IGSF9, also known as Dasm1, is an approximately 130 kDa transmembrane protein that plays a role in neuronal synapse maintenance and function (1). Mature mouse Dasm1 consists of a 714 amino acid (aa) extracellular domain (ECD) with 5 Ig-like domains and 2 fibronectin type-3 domains, a 21 aa transmembrane segment, and a 424 aa cytoplasmic domain (2). Within the ECD, mouse Dasm1 shares 90% and 96% aa sequence identity with human and rat Dasm1, respectively. Alternative splicing generates an additional isoform that is truncated following the fifth Ig-like domain. Dasm1 is expressed in the dorsal root and trigeminal ganglia, forebrain, cortex, dentate gyrus, pyramidal cells, Purkinje cells, and hippocampal CA1 interneurons (2-5). It localizes to dendrites, cell bodies, and post-synaptic densities (3, 6). Dasm1 functions as a homophilic adhesion protein that supports the maintenance of inhibitory synapses as well as inhibitory neurotransmission (5, 6).

References

  1. Hansen, M. and P.S. Walmod (2013) Neurochem. Res. 38:1236.
  2. Doudney, K. et al. (2002) Genomics 79:663.
  3. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13341.
  4. Mishra, A. et al. (2008) Mol. Cell. Biol. 28:2782.
  5. Mishra, A. et al. (2014) J. Neurosci. 34:4187.
  6. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13346.

Long Name

Immunoglobulin Superfamily, Member 9

Alternate Names

Dasm1, FP18798, IGSF9A, KIAA1355, Nrt1, Protein Turtle Homolog A, TUTLA

Entrez Gene IDs

57549 (Human); 93842 (Mouse); 304982 (Rat)

Gene Symbol

IGSF9

UniProt

Q05BQ1

Additional IGSF9 Products

Product Documents for Recombinant Mouse IGSF9 Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse IGSF9 Protein, CF

For research use only

Related Research Areas

Integrins and Associated Molecules

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