Recombinant Mouse IL-15 Protein

Carrier Free

Catalog # Availability Size / Price Qty
447-ML-010/CF

With Carrier

Catalog # Availability Size / Price Qty
447-ML-010
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (50)
FAQs
Reviews (1)

Recombinant Mouse IL-15 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 2-15 ng/mL.
Source
E. coli-derived mouse IL-15 protein
Asn49-Ser162, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
13.4 kDa

Product Datasheets

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447-ML (with carrier)

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447-ML/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

447-ML

Formulation Lyophilized from a 0.2 μm filtered solution in Tris and NaCl with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

447-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-15

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases (1, 2). Mature mouse IL-15 shares 70% and 96% amino acid sequence identity with human and rat IL-15, respectively. IL-15 binds with high affinity to IL‑15 R alpha (3). It binds with lower affinity to a complex of IL‑2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (4). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (5). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (6). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (5). In human and mouse, soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding and bind up nearly all the IL-15 in circulation (7-9). Soluble IL-15 R alpha functions as an inhibitor that limits IL-15 action (3, 8). Ligation of membrane‑associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells (10). IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells (11-15). An important component of these functions is the ability of IL-15 to induce dendritic cell differentiation and inflammatory activation (10, 13). IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells (16). It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (17).

References
  1. De Sabatino, A. et al. (2011) Cytokine Growth Factor Rev. 22:19.
  2. Grabstein, K. et al. (1994) Science 264:965.
  3. Giri, J.G. et al. (1995) EMBO J. 14:3654.
  4. Giri, J. et al. (1994) EMBO J. 13:2822.
  5. Dubois, S. et al. (2002) Immunity 17:537.
  6. Castillo, E.F. and K.S. Schluns (2012) Cytokine 59:479.
  7. Budagian, V. et al. (2004) J. Biol. Chem. 279:40368.
  8. Mortier, E. et al. (2004) J. Immunol. 173:1681.
  9. Bergamaschi, C. et al. (2012) Blood 120:e1.
  10. Budagian, V. et al. (2004) J. Biol. Chem. 279:42192.
  11. Mortier, E. et al. (2003) J. Exp. Med. 205:1213.
  12. Gordy, L.E. et al. (2011) J. Immunol. 187:6335.
  13. Harris, K.M. (2011) J. Leukoc. Biol. 90:727.
  14. Xia, J. et al. (2010) Clin. Immunol. 134:130.
  15. Schluns, K.S. et al. (2002) J. Immunol. 168:4827.
  16. Davies, E. et al. (2010) J. Leukoc. Biol. 88:529.
  17. Barra, N.G. et al. (2010) Obesity 18:1601.
Long Name
Interleukin 15
Entrez Gene IDs
3600 (Human); 16168 (Mouse); 25670 (Rat); 102119613 (Cynomolgus Monkey); 493682 (Feline)
Alternate Names
IL15; IL-15; IL-15MGC9721; interleukin 15; interleukin-15

Citations for Recombinant Mouse IL-15 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

50 Citations: Showing 1 - 10
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  1. A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice
    Authors: PL Vu, J Vadakekola, S Idri, H Nicholls, M Cavaignac, S Reeder, MA Khan, D Christense, AG Pockley, SE McArdle
    Cancers, 2022;14(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes
    Authors: K Hashimoto, Y Yamada, K Sekiguchi, S Matsuda, S Mori, T Matsumoto
    Journal of dermatological science, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Deconvoluting global cytokine signaling networks in natural killer cells
    Authors: GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau
    Nature Immunology, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function
    Authors: P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park
    JCI Insight, 2021;6(21):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
    Authors: SS Ng, F De Labasti, J Yan, D Corvino, I Das, P Zhang, R Kuns, SB Chauhan, J Hou, XY Li, TCM Frame, BA McEnroe, E Moore, J Na, JA Engel, MSF Soon, B Singh, AJ Kueh, MJ Herold, M Montes de, SS Singh, PT Bunn, AR Aguilera, M Casey, M Braun, N Ghazanfari, S Wani, Y Wang, FH Amante, CL Edwards, A Haque, WC Dougall, OP Singh, AG Baxter, MWL Teng, A Loukas, NL Daly, N Cloonan, MA Degli-Espo, J Uzonna, WR Heath, T Bald, SK Tey, K Nakamura, GR Hill, R Kumar, S Sundar, MJ Smyth, CR Engwerda
    Nat. Immunol., 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  6. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells
    Authors: GM Wiedemann, S Grassmann, CM Lau, M Rapp, AV Villarino, C Friedrich, G Gasteiger, JJ O'Shea, JC Sun
    Cell Reports, 2020;33(11):108498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Innate T-&alpha&beta lymphocytes as new immunological components of anti-tumoral "off-target" effects of the tyrosine kinase inhibitor dasatinib
    Authors: A Barbarin, M Abdallah, L Lefèvre, N Piccirilli, E Cayssials, L Roy, JM Gombert, A Herbelin
    Sci Rep, 2020;10(1):3245.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers
    Authors: X Yang, J Zhao, S Duan, X Hou, X Li, Z Hu, Z Tang, F Mo, X Lu
    Theranostics, 2019;9(14):4066-4083.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
    Authors: N Simonovi?, A Witalisz-S, K Meissl, C Lassnig, U Reichart, T Kolbe, M Farlik, C Bock, V Sexl, M Müller, B Strobl
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  10. Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a
    Authors: S Xiao, W Zhang, NR Manley
    PLoS ONE, 2018;13(2):e0193188.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties
    Authors: A Van Acker, K Gronke, A Biswas, L Martens, Y Saeys, J Filtjens, S Taveirne, E Van Ammel, T Kerre, P Matthys, T Taghon, B Vandekerck, J Plum, IR Dunay, A Diefenbach, G Leclercq
    Cell Rep, 2017;19(7):1431-1443.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis
    Authors: AP Vicari, AM Schoepfer, B Meresse, L Goffin, O Léger, S Josserand, N Guégan, S Yousefi, A Straumann, N Cerf-Bensu, HU Simon, Y Chvatchko
    MAbs, 2017;0(0):0.
    Species: Human
    Sample Types: Protein
    Applications: Surface Plasmon Resonance
  13. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection
    Authors: HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
    Authors: I Kavazovi?, M Lenarti?, V Jelen?i?, S Jurkovi?, NA Lemmermann, S Jonji?, B Poli?, FM Wensveen
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
    Authors: Fabrizio Antonangel
    Oncoimmunology, 2016;5(10):e1218105.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness
    Authors: P Holmkvist, L Pool, K Hägerbrand, WW Agace, A Rivollier
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
    Authors: RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi
    PLoS Pathog, 2016;12(4):e1005545.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire
    Authors: David A Hildeman
    J. Immunol., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
    Authors: Fiege J, Burbach B, Shimizu Y
    J Immunol, 2015;195(7):3119-28.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
    Authors: Pobezinsky L, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry T, Kimura M, Sharrow S, Guinter T, Feigenbaum L, Singer A
    Nat Immunol, 2015;16(5):517-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Drak2 Does Not Regulate TGF-beta Signaling in T Cells.
    Authors: Harris T, McGargill M
    PLoS ONE, 2015;10(5):e0123650.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.
    Authors: Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, Pellegrini M, Hildeman D
    Cell Death Differ, 2015;22(1):174-84.
    Species: Mouse
    Sample Types: Whole Organism
    Applications: In vivo
  23. Central memory CD8+ T lymphocytes mediate lung allograft acceptance.
    Authors: Krupnick A, Lin X, Li W, Higashikubo R, Zinselmeyer B, Hartzler H, Toth K, Ritter J, Berezin M, Wang S, Miller M, Gelman A, Kreisel D
    J Clin Invest, 2014;124(3):1130-43.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  24. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
    Authors: Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T
    Nat Immunol, 2014;15(8):749-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface.
    Authors: Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, Saudemont A
    PLoS ONE, 2014;9(7):e103254.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives.
    Authors: Pennati A, Deng J, Galipeau J
    PLoS ONE, 2014;9(9):e106724.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  27. Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.
    Authors: Dowty, Martin E, Jesson, Michael, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini
    J Pharmacol Exp Ther, 2014;348(1):165-73.
    Species: Mouse
    Sample Types: Whole Blood
    Applications: Bioassay
  28. IL-15 is required for postexercise induction of the pro-oxidative mediators PPARdelta and SIRT1 in male mice.
    Authors: Quinn L, Anderson B, Conner J, Wolden-Hanson T, Marcell T
    Endocrinology, 2014;155(1):143-55.
    Species: Mouse
    Sample Types: In Vivo
  29. Dok1 and Dok2 proteins regulate natural killer cell development and function.
    Authors: Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, Dalod M, Vivier E, Nunes J
    EMBO J, 2014;33(17):1928-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Galectin-9 functionally impairs natural killer cells in humans and mice.
    Authors: Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H
    J Virol, 2013;87(9):4835-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Normal development and function but impaired memory phenotype of CD8(+) T cells in transgenic mice expressing HIV-1 Nef in its natural target cells.
    Authors: Ahmed Rahim M, Chrobak P, Priceputu E, Hanna Z, Jolicoeur P
    Virology, 2013;438(2):84-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
    Authors: Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, Boudousquie C, Utzschneider D, Escobar T, Perret R, Muljo S, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo N, Held W, Gattinoni L, Romero P
    Immunity, 2013;38(4):742-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.
    Authors: Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U
    J Immunol, 2013;190(10):5128-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells.
    Authors: Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A
    Proc Natl Acad Sci U S A, 2012;109(43):17549-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  37. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.
    Authors: Kurtulus S, Tripathi P, Moreno-Fernandez ME
    J. Immunol., 2011;186(10):5729-37.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  38. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection.
    Authors: Verbist KC, Cole CJ, Field MB, Klonowski KD
    J. Immunol., 2011;186(1):174-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo RW, Abadie V, Tang F
    Nature, 2011;471(7337):220-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  41. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
    Authors: Pepper M, Linehan JL, Pagan AJ, Zell T, Dileepan T, Cleary PP, Jenkins MK
    Nat. Immunol., 2010;11(1):83-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  42. Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes.
    Authors: Barra NG, Reid S, MacKenzie R
    Obesity (Silver Spring), 2010;18(8):1601-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  43. STAT5 is critical to maintain effector CD8+ T cell responses.
    Authors: Tripathi P, Kurtulus S, Wojciechowski S
    J. Immunol., 2010;185(4):2116-24.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  44. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
    Authors: Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW
    J. Immunol., 2009;182(12):7398-407.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection.
    Authors: Wan N, Dai H, Wang T, Moore Y, Zheng XX, Dai Z
    J. Immunol., 2008;180(1):113-21.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  46. Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS.
    Authors: Pan W, Hsuchou H, Yu C, Kastin AJ
    J. Neurochem., 2008;106(1):313-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  47. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.
    Authors: Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, Troy AE, Kobuley DE, Kastelein RA, Cua DJ, Yu Y, Artis D
    J. Exp. Med., 2008;205(10):2191-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  48. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
    Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
    Blood, 2007;109(5):2234-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007;178(4):2018-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
    Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
    J. Immunol., 2003;170(4):2106-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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By Katie Myers on 11/14/2022
Application: Immunoassay Standard
Reason for Rating: Seemed well-purified and worked for our purposes.

We used this as a standard for a mouse ELISA.