IL-15 Signaling Pathways

Click on the "Effects" button below to reveal the primary biological effects of IL-15 signaling in different immune cell types. Click on one of the other cytokines below for information on a different common cytokine receptor gamma-chain family member.

Common
gamma chain
Common
gamma chain
IL-15
IL-15
IL-15 R alpha
IL-15 R alpha
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
IL-15 R alpha
IL-15 R alpha
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common gamma chain
Common gamma chain
ProductsClose
Jak1
Jak1
ProductsClose
ProductsClose
Jak3
Jak3
ProductsClose
ProductsClose
Jak1
Jak1
ProductsClose
ProductsClose
Jak3
Jak3
ProductsClose
ProductsClose
STAT3
STAT3
ProductsClose
STAT5
STAT5
IL-15
IL-15
STAT Dimer
STAT Dimer
Cis-presentation
Cis-presentation
Trans-presentation
Trans-presentation

IL-15 Receptor-Expressing Cells:
T cells, natural killer cells,
natural killer T cells,
dendritic cells, monocytes

IL-15 Receptor-Expressing Cells:
T cells, natural killer cells,
natural killer T cells,
dendritic cells, monocytes

PI 3-K
PI 3-K
ProductsClose
PDK-1
PDK-1
ProductsClose
Akt/PKB
Akt/PKB
p70 S6K
p70 S6K
ProductsClose
Bad
Bad
ProductsClose
GSK-3
GSK-3
Forkhead
Forkhead
ProductsClose
IRS
IRS
ProductsClose
ProductsClose
Shc
Shc
ProductsClose
ProductsClose
GRB2
GRB2
ProductsClose
ProductsClose
SOS
SOS
ProductsClose
ProductsClose
Ras
Ras
ProductsClose
Raf
Raf
MEK1/2
MEK1/2
ERK1/2
ERK1/2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
PIP2
PIP2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
ProductsClose
PIP3
PIP3
ProductsClose

Anti-Apoptotic

Anti-Apoptotic

Mitogenic

Mitogenic

Target Genes
Target Genes

Overview of IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-15 (IL-15) is a four alpha-helix bundle cytokine that is structurally and functionally related to IL-2. It is produced primarily by dendritic cells, monocytes, and epithelial cells. The heterotrimeric IL-15 receptor complex consists of a unique IL-15 R alpha subunit, IL-2/IL-15 R beta, and the common gamma-chain/IL-2 R gamma subunit. Unlike IL-2, IL-15 binds with high affinity to IL-15 R alpha, which then associates with a complex composed of the IL-2/IL-15 R beta and common gamma-chain/IL-2 R gamma subunits, expressed either on the same cell (cis-presentation) or on a different cell (trans-presentation). IL-15 signaling is essential for normal immune system functions. It stimulates T cell proliferation and inhibits IL-2-mediated activation-induced cell death. In addition, IL-15 is required for the development, survival, and activation of natural killer (NK) cells, homeostasis of natural killer T (NKT) cells and intraepithelial lymphocytes, and maintenance of naïve and memory CD8+ T cells. Both IL-15- and IL-15 R alpha-deficient mice lack NK cells and have severely reduced numbers of NKT cells, memory CD8+ T cells, and specific subsets of intestinal intraepithelial lymphocytes.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.