Show Categories

IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the links shown in the Explore Pathways box below to see either the IL-15 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

IL-15
IL-15
IL-15 R
IL-15 R
Activated T Cell
Activated T Cell
ProductsClose
Regulates Activated
T Cell Proliferation
Regulates Activated
T Cell Proliferation
ProductsClose
IL-2 R
IL-2 R
IL-15 R
IL-15 R
IL-2
IL-2
ProductsClose
IL-15
IL-15
IL-15 R
IL-15 R
IL-2 R
IL-2 R
Fas L or TNF-alpha
Fas L or TNF-alpha
Fas, TNF RI,
or TNF RII
Fas, TNF RI,
or TNF RII
Proliferating/Activated
CD4+ T Cells
Proliferating/Activated
CD4+ T Cells
ProductsClose
Antigen
Antigen
ProductsClose

Activation-Induced Cell Death

Activation-Induced Cell Death

ProductsClose

Inhibits Activation-Induced Cell Death

Inhibits Activation-Induced Cell Death

ProductsClose
Inhibits Activation-Induced
Cell Death
Inhibits Activation-Induced
Cell Death
ProductsClose
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Dendritic Cell
Dendritic Cell
ProductsClose
Naive
CD8+ T Cell
Naive
CD8+ T Cell
ProductsClose

Proliferation/Survival

Proliferation/Survival

ProductsClose

Proliferation/Survival

Proliferation/Survival

ProductsClose
Antigen
Antigen
ProductsClose
Activated CD8+ T Cell
Activated CD8+ T Cell
ProductsClose
Memory
CD8+ T Cell
Memory
CD8+ T Cell
ProductsClose

Proliferation/Survival

Proliferation/Survival

ProductsClose
Regulates the Maintenance
of Naive & Memory CD8+ T Cells
Regulates the Maintenance
of Naive & Memory CD8+ T Cells
ProductsClose
IL-15
IL-15
IL-15 R
IL-15 R
gamma delta TCR
gamma delta TCR
ProductsClose
Bcl-2
Bcl-2
ProductsClose
Intraepithelial
Lymphocyte
Intraepithelial
Lymphocyte
ProductsClose

gamma delta T Cell Survival/Expansion

gamma delta T Cell Survival/Expansion

ProductsClose
Protects Intestinal
Intraepithelial Lymphocytes
Protects Intestinal
Intraepithelial Lymphocytes
ProductsClose
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Accessory Cell
Accessory Cell
ProductsClose
Natural Killer
T Cells
Natural Killer
T Cells
ProductsClose

Natural Killer T Cell
Expansion/Homeostasis

Natural Killer T Cell
Expansion/Homeostasis

ProductsClose
Promotes Expansion
& Homeostasis of NKT Cells
Promotes Expansion
& Homeostasis of NKT Cells
ProductsClose
IL-15
IL-15
IL-15 R
IL-15 R
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Natural Killer Cell
Precursor
Natural Killer Cell
Precursor
ProductsClose

Development

Development

ProductsClose

Survival

Survival

ProductsClose
Accessory Cell
Accessory Cell
ProductsClose
Natural Killer Cell
Natural Killer Cell
ProductsClose

Natural Killer Cell Development/Survival

Natural Killer Cell Development/Survival

ProductsClose
Promotes Natural Killer Cell
Development & Survival
Promotes Natural Killer Cell
Development & Survival
ProductsClose
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
IFN-gamma
IFN-gamma
ProductsClose
GM-CSF
GM-CSF
ProductsClose
MIP-1 alpha/beta
MIP-1 alpha/beta
Granzymes
Granzymes
Dendritic Cell
Dendritic Cell
ProductsClose
Natural Killer Cell
Natural Killer Cell
ProductsClose
Perforin/
Perforin/
ProductsClose
Target Cell
Target Cell
ProductsClose

Cell Death

Cell Death

ProductsClose

Natural Killer Cell-Mediated Cell Death

Natural Killer Cell-Mediated Cell Death

ProductsClose
Promotes Dendritic Cell Priming
of Natural Killer Cells
Promotes Dendritic Cell Priming
of Natural Killer Cells
ProductsClose
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Overview of IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-15 (IL-15) is a four alpha-helix bundle cytokine that is structurally and functionally related to IL-2. It is produced primarily by dendritic cells, monocytes, and epithelial cells. The heterotrimeric IL-15 receptor complex consists of a unique IL-15 R alpha subunit, IL-2/IL-15 R beta, and the common gamma-chain/IL-2 R gamma subunit. Unlike IL-2, IL-15 binds with high affinity to IL-15 R alpha, which then associates with a complex composed of the IL-2/IL-15 R beta and common gamma-chain/IL-2 R gamma subunits, expressed either on the same cell (cis-presentation) or on a different cell (trans-presentation). IL-15 signaling is essential for normal immune system functions. It stimulates T cell proliferation and inhibits IL-2-mediated activation-induced cell death. In addition, IL-15 is required for the development, survival, and activation of natural killer (NK) cells, homeostasis of natural killer T (NKT) cells and intraepithelial lymphocytes, and maintenance of naïve and memory CD8+ T cells. Both IL-15- and IL-15 R alpha-deficient mice lack NK cells and have severely reduced numbers of NKT cells, memory CD8+ T cells, and specific subsets of intestinal intraepithelial lymphocytes.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.

IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types background image 1