IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the buttons below to see either the IL-15 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

IL-15
IL-15
IL-15 R
IL-15 R
Activated T Cell
Activated T Cell
Regulates Activated
T Cell Proliferation
Regulates Activated
T Cell Proliferation
IL-2 R
IL-2 R
IL-15 R
IL-15 R
IL-2
IL-2
ProductsClose
IL-15
IL-15
IL-15 R
IL-15 R
IL-2 R
IL-2 R
Fas L or TNF-alpha
Fas L or TNF-alpha
Fas, TNF RI,
or TNF RII
Fas, TNF RI,
or TNF RII
Proliferating/Activated
CD4+ T Cells
Proliferating/Activated
CD4+ T Cells
Antigen
Antigen

Activation-Induced Cell Death

Activation-Induced Cell Death

Inhibits Activation-Induced Cell Death

Inhibits Activation-Induced Cell Death

Inhibits Activation-Induced
Cell Death
Inhibits Activation-Induced
Cell Death
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Dendritic Cell
Dendritic Cell
Naive
CD8+ T Cell
Naive
CD8+ T Cell

Proliferation/Survival

Proliferation/Survival

Proliferation/Survival

Proliferation/Survival

Antigen
Antigen
Activated CD8+ T Cell
Activated CD8+ T Cell
Memory
CD8+ T Cell
Memory
CD8+ T Cell

Proliferation/Survival

Proliferation/Survival

Regulates the Maintenance
of Naive & Memory CD8+ T Cells
Regulates the Maintenance
of Naive & Memory CD8+ T Cells
IL-15
IL-15
IL-15 R
IL-15 R
gamma delta TCR
gamma delta TCR
ProductsClose
Bcl-2
Bcl-2
ProductsClose
Intraepithelial
Lymphocyte
Intraepithelial
Lymphocyte

gamma delta T Cell Survival/Expansion

gamma delta T Cell Survival/Expansion

Protects Intestinal
Intraepithelial Lymphocytes
Protects Intestinal
Intraepithelial Lymphocytes
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Accessory Cell
Accessory Cell
Natural Killer
T Cells
Natural Killer
T Cells

Natural Killer T Cell
Expansion/Homeostasis

Natural Killer T Cell
Expansion/Homeostasis

Promotes Expansion
& Homeostasis of NKT Cells
Promotes Expansion
& Homeostasis of NKT Cells
IL-15
IL-15
IL-15 R
IL-15 R
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
Natural Killer Cell
Precursor
Natural Killer Cell
Precursor

Development

Development

Survival

Survival

Accessory Cell
Accessory Cell
Natural Killer Cell
Natural Killer Cell

Natural Killer Cell Development/Survival

Natural Killer Cell Development/Survival

Promotes Natural Killer Cell
Development & Survival
Promotes Natural Killer Cell
Development & Survival
IL-15 R alpha
IL-15 R alpha
IL-15
IL-15
ProductsClose
IL-2/IL-15 R beta
IL-2/IL-15 R beta
ProductsClose
Common
gamma chain
Common
gamma chain
IFN-gamma
IFN-gamma
ProductsClose
GM-CSF
GM-CSF
ProductsClose
MIP-1 alpha/beta
MIP-1 alpha/beta
Granzymes
Granzymes
Dendritic Cell
Dendritic Cell
Natural Killer Cell
Natural Killer Cell
Perforin/
Perforin/
Target Cell
Target Cell

Cell Death

Cell Death

Natural Killer Cell-Mediated Cell Death

Natural Killer Cell-Mediated Cell Death

Promotes Dendritic Cell Priming
of Natural Killer Cells
Promotes Dendritic Cell Priming
of Natural Killer Cells

Overview of IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-15 (IL-15) is a four alpha-helix bundle cytokine that is structurally and functionally related to IL-2. It is produced primarily by dendritic cells, monocytes, and epithelial cells. The heterotrimeric IL-15 receptor complex consists of a unique IL-15 R alpha subunit, IL-2/IL-15 R beta, and the common gamma-chain/IL-2 R gamma subunit. Unlike IL-2, IL-15 binds with high affinity to IL-15 R alpha, which then associates with a complex composed of the IL-2/IL-15 R beta and common gamma-chain/IL-2 R gamma subunits, expressed either on the same cell (cis-presentation) or on a different cell (trans-presentation). IL-15 signaling is essential for normal immune system functions. It stimulates T cell proliferation and inhibits IL-2-mediated activation-induced cell death. In addition, IL-15 is required for the development, survival, and activation of natural killer (NK) cells, homeostasis of natural killer T (NKT) cells and intraepithelial lymphocytes, and maintenance of naïve and memory CD8+ T cells. Both IL-15- and IL-15 R alpha-deficient mice lack NK cells and have severely reduced numbers of NKT cells, memory CD8+ T cells, and specific subsets of intestinal intraepithelial lymphocytes.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.