Recombinant Mouse IL-20 R beta Fc Chimera Protein, CF Summary
|Mouse IL-20 R beta
Accession # NP_001028715
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: IL-20 R beta
IL-20 receptor beta (IL-20 R beta ), also known as IL-20 R2, is a type I transmembrane glycoprotein in the class II cytokine receptor family. These receptors are characterized by tandem fibronectin type III domains in their extracellular region and the lack of a WSXWS motif (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1). Based on the structure of the human receptor, mouse IL-20 R beta should contain a 202 amino acid (aa) extracellular domain (ECD) with two fibronectin type III domains, a 16 aa transmembrane segment, and a 44 aa cytoplasmic domain (2). Within the ECD, mouse IL-20 R beta will share 81% aa sequence identity with human IL-20 R beta. It shares 18%‑29% aa sequence identity with the mouse class II cytokine receptors IFN-alpha R1, IFN-alpha R2, IFN-gamma R1, IFN-gamma R2, IL-10 R alpha, IL-10 R beta, IL-20 R alpha, IL-22BP, IL-22 R alpha, IL-28 R, and tissue factor. IL-20 R beta is generally expressed in psoriatic skin (keratinocytes and select endothelium), rheumatoid arthritis synovial membranes, and hepatocytes of LPS-treated mice, and it contributes to the local inflammatory reaction (3‑6). IL-20 R beta heterodimerizes with IL-20 R alpha to form the receptor complex that mediates IL-19, IL-20 and IL-24 signals (3, 7‑10). It also heterodimerizes with IL-22 R to form the functional receptor complex for IL-20 and IL-24 (7‑9). Binding of these IL-10 family class II cytokines to their receptors induces activation of the JAK-STAT signal transduction pathway.
- Langer, J.A. et al. (2004) Cytokine Growth Factor Rev. 15:33.
- Accession # NP_001032323 and SwissProt # Q6UXL0.
- Blumberg, H. et al. (2001) Cell 104:9.
- Hsu, Y.-H. et al. (2006) Arthritis Rheum. 54:2722.
- Wegenka, U.M. et al. (2007) J. Hepatol. 46:257.
- Chan, J.R. et al. (2006) J. Exp. Med. 203:2577.
- Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517.
- Dumoutier, L. et al. (2001) J. Immunol. 167:3545.
- Wang, M. et al. (2002) J. Biol. Chem. 277:7341.
- Pletnev, S. et al. (2003) Biochemistry 42:12617.
Citations for Recombinant Mouse IL-20 R beta Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-&kappaB and p38MAPK activation and c-Fos expression in RAW264.7 cells
Authors: M Tsubaki, T Takeda, T Matsuda, Y Yamamoto, A Higashinak, K Yamamoto, K Tsurushima, T Ishizaka, S Nishida
Sample Types: Whole Cells
Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.
Authors: Uto-Konomi A, Miyauchi K, Ozaki N
PLoS ONE, 2012;7(7):e40343.
Sample Types: Whole Tissue
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