Recombinant Mouse LRRN4 His-tag Protein, CF Summary
Gln22-Ser676, with a C-terminal 6-His tag
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 1 mg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
LRRN4 (Leucine-rich repeat neuronal protein 4) is a type I transmembrane protein that is a member of the LRRN family. It is expressed in lung, heart, ovary, and neuronal tissues (1-3). Mature mouse LRRN4 is composed of a 657 amino acid (aa) extracellular domain (ECD) that includes ten LRRs, one LRRCT and a fibronectin type-III like domain, a 21 aa transmembrane segment, and a 36 aa cytoplasmic domain. Within the ECD, mouse LRRN4 shares 66% and 84% aa sequence identity with human and rat LRRN4, respectively. LRRN4-deficient mice show defects in the memory retention, suggesting this protein may play an important role in hippocampus-dependent long-lasting memory (1). In addition, LRRN4 is found in about 8% dorsal root ganglion (DRG) neurons (2). These neurons are small-sized neurons that function as nociceptors. LRRN4 expression was decreased in the DRG by sciatic axotomy suggesting that LRRN4 might function as a synaptic adhesion molecule to maintain nociceptive circuits (2). LRRN4 is also expressed in primary mesothelial cells and may be developed as a maker for detection of mesothelioma antigens (4).
- Bando, T. et al. (2005) Mol. Cell. Biol. 25:4166.
- Bando, T. et al. (2012) Neurosci. Lett. 531:24.
- Bando, T. et al. (2013) Neurosci. Lett. 548:73.
- Kanamori-Katayama, M. (2011) PloS. One. 6(10):e24391.
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