Recombinant Mouse NPRA/NPR1 Protein, CF Summary
Ser29-Glu469, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 250 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins.
Mouse Natriuretic Peptide Receptor-1 (NPR1), also known as NPRA, ANP-R1 or guanlyl cyclase-A, is a 130 kDa member of the guanylyl cyclase family of proteins. NPR1 is a type I transmembrane glycoprotein that contains a 441 amino acid extracellular domain (ECD) (aa 29‑469) for ligand binding, and a 567 amino acid cytoplasmic region that contains both a protein kinase domain and a guanylate cyclase domain. NPR1 is expressed most highly in kidney, adrenal and adipose tissue (1). NPR1 operates as an oligomer and binds both ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). Binding of ANP to the extracellular ligand binding domain, plus ATP to the intracellular kinase domain activates a cytoplasmic guanylate cyclase (1). This process induces bronchodilation and a reduction in blood pressure (2). Over the extracellular domain, mouse NPR1 is 97% and 86% identical to rat and human NPR1, respectively.
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