Recombinant Mouse OSCAR Fc Chimera Protein, CF Summary
Accession # Q8VBT3
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||
When Bovine College I is coated at 10 µg/mL, Recombinant MouseOSCAR Fc Chimera binds with an ED50 of 80‑640 ng/mL.
OSCAR (Osteoclast-associated immunoglobulin-like receptor), is a type I transmembrane protein of the leukocyte receptor complex (LRC) family (1). The mature mouse OSCAR includes a 213 amino acid (aa) extracellular domain (ECD) with two Ig domains homology to PIR family proteins, a 17 aa transmembrane region, and a 17 aa cytoplasmic domain. The ECD of mouse OSCAR shares 77% and 84% aa sequence identity with the ECD of human and rat OSCAR, respectively (2). OSCAR is specifically expressed by pre-osteoclasts and signals via FcR gamma (3). OSCAR co-stimulates one of the major FcR gamma‑associated pathways required for osteoclastogenesis in vivo (3). Collagen type I and collagen type II serve as ligands for OSCAR (4). OSCAR binds to specific motifs within fibrillary collagens in the extracellular matrix (ECM) (3). OSCAR promoted osteoclastogenesis in vivo, and its binding to the collagen motif led to signaling that increased numbers of osteoclasts in culture (3). OSCAR contains two Ig domains, D1 and D2. Direct binding assays on OSCAR molecules showed that D2, but not D1, is critical for collagen binding (5). OSCAR may contribute to the pathogenesis and severity of a number of diseases including osteoporosis, atherosclerosis, chronic obstructive pulmonary disease and rheumatoid arthritis (5).
- Kim, N. et al. (2002) J. Exp. Med. 195:201.
- Haywood, J. et al. (2016) Proc. Natl. Acad. Sci. USA 113:1038.
- Barrow, A.D. et al. (2011) J. Clin. Invest. 121:3505.
- Shultz, H.S. et al. (2016) Eur. J. Immunol. 46:952.
- Zhou, L. et al. (2016) Blood 127:529.
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