Recombinant Mouse OSCAR Fc Chimera Protein, CF

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Recombinant Mouse OSCAR Fc Chimera Protein, CF Binding Activity
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Product Details

Recombinant Mouse OSCAR Fc Chimera Protein, CF Summary

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Bovine Collagen I is coated at 10 µg/mL, Recombinant Mouse OSCAR Fc Chimera binds with an ED50 of 80-640 ng/mL.
Mouse myeloma cell line, NS0-derived mouse OSCAR protein
Accession # Q8VBT3
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
49 kDa
56-66 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 12 months from date of receipt, ≤ -20 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Data Image

Binding Activity Binding Activity View Larger

When Bovine College I is coated at 10 µg/mL, Recombinant MouseOSCAR Fc Chimera binds with an ED50 of 80‑640 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: OSCAR

OSCAR (Osteoclast-associated immunoglobulin-like receptor), is a type I transmembrane protein of the leukocyte receptor complex (LRC) family (1). The mature mouse OSCAR includes a 213 amino acid (aa) extracellular domain (ECD) with two Ig domains homology to PIR family proteins, a 17 aa transmembrane region, and a 17 aa cytoplasmic domain. The ECD of mouse OSCAR shares 77% and 84% aa sequence identity with the ECD of human and rat OSCAR, respectively (2). OSCAR is specifically expressed by pre-osteoclasts and signals via FcR gamma (3). OSCAR co-stimulates one of the major FcR gamma‑associated pathways required for osteoclastogenesis in vivo (3). Collagen type I and collagen type II serve as ligands for OSCAR (4). OSCAR binds to specific motifs within fibrillary collagens in the extracellular matrix (ECM) (3). OSCAR promoted osteoclastogenesis in vivo, and its binding to the collagen motif led to signaling that increased numbers of osteoclasts in culture (3). OSCAR contains two Ig domains, D1 and D2. Direct binding assays on OSCAR molecules showed that D2, but not D1, is critical for collagen binding (5). OSCAR may contribute to the pathogenesis and severity of a number of diseases including osteoporosis, atherosclerosis, chronic obstructive pulmonary disease and rheumatoid arthritis (5).

  1. Kim, N. et al. (2002) J. Exp. Med. 195:201.
  2. Haywood, J. et al. (2016) Proc. Natl. Acad. Sci. USA 113:1038.
  3. Barrow, A.D. et al. (2011) J. Clin. Invest. 121:3505.
  4. Shultz, H.S. et al. (2016) Eur. J. Immunol. 46:952.
  5. Zhou, L. et al. (2016) Blood 127:529.
Long Name
Osteoclast-associated Receptor
Entrez Gene IDs
126014 (Human); 232790 (Mouse)
Alternate Names
hOSCAR; MGC33613; OSCAR; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; osteoclast associated, immunoglobulin-like receptor; osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIGR3; PIgR-3; Poly-Ig receptor 3; Polymeric immunoglobulin receptor 3


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