Recombinant Mouse Reg2 Protein, CF

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Recombinant Mouse Reg2 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Able to significantly enhance neurite outgrowth when immobilized at 3-30 μg/mL on a nitrocellulose-coated microplate.
Chinese Hamster Ovary cell line, CHO-derived mouse Reg2 protein
Gln23-Ala173, with an N-terminal Met
Accession #
N-terminal Sequence
Predicted Molecular Mass
17 kDa
18 kDa, reducing conditions

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: Reg2

Mouse Reg2 (Islets of Langerhans regenerating protein 2), also known as Reg‑II, Lithostathine 2, PTP2 (pancreatic thread protein 2) and PSP2 (pancreatic stone protein 2), is a member of the Reg family of secreted C‑type lectin domain‑containing pancreatic proteins (1, 2). Reg2 forms a subfamily with mouse and human Reg1 molecules (1). The mouse Reg2 cDNA encodes 173 amino acids (aa) including the 22 aa signal sequence and the 151 aa secreted mature protein. Mouse Reg2 shares approximately 83% aa sequence identity with hamster Reg2, but no Reg2 ortholog exists in humans or rats (1, 2). Reg proteins are thought to be stress response proteins that stimulate proliferation, particularly in beta cells of pancreatic islets (1). Reg2 is expressed primarily by acinar cells in the normal exocrine pancreas, and is up‑regulated in NOD (non-obese diabetic) islets, hyperplastic islets, regenerating islets or in response to pancreatic injury or pancreatitis (1‑5). IFN‑ beta causes Reg2 up‑regulation in early‑onset diabetic NOD mice or in a NOD insulinoma cell line (4). Reg2 is also up‑regulated in mice lacking the pancreas‑expressed keratin K8, and is thought to be regulated by keratin filament organization (3). It is proposed to serve as an autoantigen in NOD mouse immune‑mediated type I diabetes models (4).

  1. Liu, J.-L. et al. (2008) Endocrine Metab. Immune Disord. Drug Targets 8:1.
  2. Unno, M. et al. (1993) J. Biol. Chem. 268:15974.
  3. Zhong, B. et al. (2007) Mol. Biol. Cell 18:4969.
  4. Gurr, W. et al. (2007) Diabetes 56:34.
  5. Lu, Y. et al. (2006) Am. J. Physiol. Endocrinol. Metab. 291:E50.
  6. Baeza, N. et al. (1997) FEBS Lett. 416:364.
  7. Planas, R. et al. (2006) Diabetologia 49:2379.
Long Name
Regenerating Islet-derived 2
Entrez Gene IDs
19693 (Mouse)
Alternate Names
Reg2; regenerating islet-derived 2; RegII


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