Recombinant Mouse SECTM1A Fc Chimera Protein, CF

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Recombinant Mouse SECTM1A Fc Chimera Protein Binding Activity
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Product Details
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Recombinant Mouse SECTM1A Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Mouse CD7 (Catalog # 8145-CD) is immobilized at 1 μg/mL, 100 μL/well, the concentration of Recombinant Mouse SECTM1A Fc Chimera that produces 50% of the optimal binding response is 30-150 ng/mL.
Mouse myeloma cell line, NS0-derived mouse SECTM1A protein
Accession # NP_663348
N-terminus C-terminus
Accession #
N-terminal Sequence
Gln28 predicted: No results obtained, sequencing might be blocked
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
42.6 kDa (monomer)
55-66 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity Recombinant Mouse SECTM1A Fc Chimera Protein Binding Activity View Larger

When Recombinant Recombinant Mouse CD7 (Catalog # 8145-CD) is immobilized at 1 µg/mL, Recombinant Mouse SECTM1A Fc Chimera (Catalog # 7837-ST) binds with an ED50 of 30-150 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: SECTM1A

SECTM1A (secreted and transmembrane 1A), is 192 amino acid (aa) protein that shares approximately 45‑51%, 81%, and 43% aa sequence identity with human SECTM1 (also called K12), rat SECTM1, and mouse SECTM1B/K12, respectively, and appears to share structural and functional characteristics with other SECTM1 proteins. Human SECTM1 can be found either found as an approximately 27 kDa intracellular type I transmembrane protein that shows a perinuclear, Golgi‑like staining pattern, or as a 20 kDa soluble, secreted form, and is produced by some myeloid cells and by thymic epithelia and fibroblasts (1‑3). Stimulation with IFN‑ gamma is often necessary to detect human SECTM1 expression, and it is thought to be an interferon early‑response gene (1‑5). Mouse SECTM1A cDNA encodes a signal sequence, an extracellular domain with four potential N‑linked glycosylation sites, a transmembrane sequence, and a very short (approximately 6 aa) cytoplasmic sequence (6). SECTM1 proteins from human and mouse show species‑specific binding of CD7 and co‑stimulation of T cells, including enhancement of CD3‑induced proliferation (2‑4).

  1. Slentz-Kesler, K.A. et al. (1998) Genomics 47:327.
  2. Lam, G.K. et al. (2005) J. Clin. Immunol. 25:41.
  3. Wang, T. et al. (2012) J. Leukoc. Biol. 91:449.
  4. Lyman, S.D. et al. (2000) J. Biol. Chem. 275:3431.
  5. Huyton, T. et al. (2011) Biochim. Biophys. Acta 1810:1294.
  6. Swiss-Prot Accession # Q921W8.
Long Name
Secreted and Transmembrane 1A
Entrez Gene IDs
209588 (Mouse); 287885 (Rat)
Alternate Names

Citation for Recombinant Mouse SECTM1A Fc Chimera Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR
    Authors: X Mu, P Wang, X Wang, Y Li, H Zhao, Q Li, K Essandoh, S Deng, T Peng, GC Fan
    J. Immunol., 2020-08-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay


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