Recombinant Mouse SLITRK4 His-tag Protein, CF Summary
Asp19-Ser618, with a C-terminal 6-His tag
2 μg/lane of Recombinant Mouse SLITRK4 was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 90-100 kDa.
SLITRK4 is an approximately 90 kDa type I transmembrane member of the SLITRK family of proteins which contain a slit-like extracellular region and a Trk-like cytoplasmic region (1). Within the extracellular domain (ECD), the mouse SLITRK4 shares 98% amino acid sequence identity with human SLITRK4. The ECD of SLITRK4 contains 6 leucine rich repeats (LRR) followed by a C-terminal LRR domain, and 6 more LRRs flanked by a pair of N- and C-terminal LRR domains (2, 3). SLITRK4 is expressed in the testis and multiple regions of the brain, particularly the cerebral cortex, cerebellum, and hippocampus (4). SLITRK4 can suppress neurite outgrowth and promote the formation of excitatory presynaptic structures (3, 5). SLITRK genes are also differentially expressed in brain tumors, including astrocytoma, oligodendroglioma, glioblastoma, medulloblastoma, and supratentorial primitive neuroectodermal tumor (PNET) (2).
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- Aruga, J. and K. Mikoshiba (2003) Mol. Cell Neurosci. 24:117.
- Yim, Y.S. et al. (2013) Proc. Natl. Acad. Sci. USA 110:4057.
- Takahashi, H. et al. (2012) Nat. Neurosci. 15:389.
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