Recombinant Mouse TMEFF2/Tomoregulin-2 Fc Protein, CF Summary
Accession # Q9QYM9.1
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
2 μg/lane of Recombinant Mouse TMEFF2/Tomoregulin‑2 Fc Chimera Protein (Catalog # 11204-TF) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 77-90 kDa and 150-180 kDa, respectively.
The transmembrane protein with an EGF-like and two Follistatin-like domains 2 (TMEFF2) encodes a 374 residue long single polypeptide, type-I transmembrane proteoglycan. It is also known as HPP1, tomoregulin (TR), transmembrane protein TENB2, cancer/testis antigen family 120, member 2 (CT120.2), and transmembrane protein containing EGF and follistatin domains (TPEF). TMEFF2 amino acid sequences are 98.9% identical for human and mouse orthologs (1). The differential methylation of TMEFF2 can be related to the response to therapy and survival outcomes of the stages of cancers such as breast, prostate, lung, bladder, colon and rectal, gallbladder, renal, oesophageal, cardiac, stomach/gastric, ovarian, multiple myeloma, glioblastoma, and mesothelioma. The range of tissue expression of TMEFF2 functions as a possible biomarker and/or therapeutic target (1). Studies showed that TMEFF2 binds and inhibits PDGF-AA (2,3). It also inhibits the proliferation of DU145 and PC3 prostate cancer cell lines (4). The amyloid-b protein, its precursor AbPP, and amyloid- b proteins AbPOs also binds TMEFF2 suggesting a neuroprotective role on Alzheimer's disease (5). TMEFF2 diverse function includes metabolism, embryonic development, cytoskeletal binding, extracellular matrix binding, chromatin binding and interaction of RNA polymerase II with DNA (6), neuronal development (7).
- Masood, M. et al. (2020) Cancers 12:3862.
- Lin, K. et al. (2011) PLoS ONE 6:e18608.
- Huang, H. et al. (2017) Sci. Rep. 7:337.
- Gery, S. et al. (2002)Oncogene 21:4739.
- Hong, H.S. et al. (2015) Alzheimers Dis. 48:731.
- Gao, L. et al. (2020) Life Sci. 243:116910.
- Horie, M. et al. (2000) Genomics 67:146.
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