Recombinant Mouse VSIG-8 Fc Chimera (Catalog # 9204-VS)inhibits anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. TheED50 for this effect is 0.5-3 μg/mL.
VSIG8 (V-set and immunoglobulin domain containing 8), also known as C1orf204, is an approximately 45 kDa type I transmembrane protein of the B7 family within the Ig superfamily. Mature mouse VSIG8 consists of a 241 amino acid (aa) extracellular domain (ECD) containing two V-type Ig-like domains, a 21 aa transmembrane domain, and a 134 aa cytoplasmic domain. Within the ECD, mouse VSIG8 shares 88% and 95% aa identity with human and rat VSIG8, respectively. Alternative splicing generates an isoform of mouse VSIG8 that lacks most of the first Ig-like domain. VSIG8 was identified from proteomic analysis of human hair shafts (1, 2). It is expressed in the hair follicle and shaft, superficial layers of the nail matrix, and superficial layers of oral epithelium (3). R&D Systems in-house testing indicates that VSIG8 inhibits the production of IL-2 by activated T cells.
Rice, R.H. et al. (2010) J. Proteome Res. 9:6752.
Lee, Y.J. et al. (2006) Mol. Cell. Proteomics 5:789.
Rice, R.H. et al. (2011) J. Invest. Dermatol. 131:1936.
V-Set and Immunoglobulin Domain Containing 8
Entrez Gene IDs:
391123 (Human); 240916 (Mouse); 289236 (Rat)
V-set and immunoglobulin domain containing 8; VSIG8
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