Recombinant Rat CSMD1 Protein, CF
Recombinant Rat CSMD1 Protein, CF Summary
Ala2081-Ser3170, with a C-terminal 6-His tag
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cub and sushi multiple domains-1 (CSMD1), also known as multiple domain complement regulator 1, is an approximately 388-kDa member of the neuronal cub and sushi multiple domains family that plays a role in the regulation of inflammation and complement activation (1). It may also act as a tumor suppressor and be involved in growth cone functions such as amoeboid motility and cell-cell interaction (2, 3). This 3535 amino acid (aa) transmembrane protein is highly expressed in the central nervous system and epithelial tissues. The rat CSMD1 extracellular domain (ECD) consists of 14 N-terminal cub domains that alternate with sushi domains, followed by 15 C-terminal sushi domains (1). Within the ECD, rat CSMD1 shares 93% and 98% sequence identity with human and mouse CSMD1, respectively.
- Kraus, D. et al. (2006) J. Immunol. 176:4419.
- Ma, C. et al. (2009) Cancer Biol. Ther. 8:907.
- Kamal, M. et al. (2010) Breast Cancer Res. Treat. 121:555.
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