Reparixin L-lysine salt

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Reparixin L-lysine salt | CAS No. 266359-93-7 | Chemokine Receptor Antagonists
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Description: Potent CXCR1 and CXCR2 allosteric antagonist
Alternative Names: Repertaxin L-lysine salt

Chemical Name:R)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide L-Lysine salt

Purity: ≥98%

Product Details

Biological Activity

Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.

Technical Data

Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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