Retigabine

Tocris Bioscience | Catalog # 6233

KV7 channel activator
Tocris Bioscience

Key Product Details

Description

KV7 channel activator

Alternative Names

Ezogabine
View all Voltage-gated Potassium Channel Activators »

Product Description

Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Product Specifications for Retigabine

Molecular Weight

303.33

Formula

C16H18FN3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate

CAS Number

150812-12-7

PubChem ID

121892

InChI Key

PCOBBVZJEWWZFR-UHFFFAOYSA-N

SMILES

CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.33 100
Ethanol 30.33 100

Preparing Stock Solutions for Retigabine

The following data is based on the product molecular weight 303.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.30 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.30 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.30 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 46 publications citing the usage of this product.

Product Documents for Retigabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Retigabine

For research use only

Customer Reviews for Retigabine (1)

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  • Retigabine studied on HEK 293 cell line : Worked ideally on experimental conditions
    Name: Farzana Islam
    Species: Human
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 09/02/2018
    For sterile test compound, dissolve Retigabine in sterile DMSO under a hood.
    The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.
    Retigabine 6233

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