Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
Biological ActivityRetigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Retigabine: chemical synthesis to clinical application.
Blackburn-Munro et al.
CNS Drug Rev., 2005;11:1
Citation for Retigabine
The citations listed below are publications that use Tocris products. Selected citations for Retigabine include:
1 Citation: Showing 1 - 1
Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle.
Authors: Afeli Et al.
PLoS One 2013;8:e75875
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The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.