Retigabine

Catalog # Availability Size / Price Qty
6233/10
6233/50
Retigabine | CAS No. 150812-12-7 | Voltage-gated Potassium Channel Activators
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Description: KV7 channel activator
Alternative Names: Ezogabine

Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Technical Data

M.Wt:
303.33
Formula:
C16H18FN3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
150812-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retigabine: chemical synthesis to clinical application.
    Blackburn-Munro et al.
    CNS Drug Rev., 2005;11:1

Product Datasheets

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Citation for Retigabine

The citations listed below are publications that use Tocris products. Selected citations for Retigabine include:

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Retigabine studied on HEK 293 cell line : Worked ideally on experimental conditions
By Farzana Islam on 09/02/2018
Application: Species: Human

The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.


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