RFRP 3 (human)
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Description: NPFF1 agonist; GnIH homolog
Alternative Names: Neuropeptide NPVF
Purity: ≥95%
Biological Activity
RFRP 3 (human) is an agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.Technical Data
M.Wt:
969.15
Formula:
C45H72N14O10
Sequence:
VPNLPQRF
(Phe-8 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
311309-27-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Hinuma et al.
Nat.Cell.Biol., 2000;2:703 -
RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
Rizwan et al.
Endocrinology, 2012;153:3770 -
Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.
Ubuka et al.
PLoS One, 2009;4:e8400
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