Catalog Number: 4683
Alternate Names: Neuropeptide NPVF
Biological Activity
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
Technical Data
  • M.Wt:
    969.15
  • Formula:
    C45H72N14O10
  • Sequence:
    VPNLPQRF

    (Phe-8 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    311309-27-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
    Rizwan et al.
    Endocrinology, 2012;153:3770
  2. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.
    Ubuka et al.
    PLoS One, 2009;4:e8400
  3. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
    Hinuma et al.
    Nat.Cell Biol., 2000;2:703

Have you used RFRP 3 (human)?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information