Agonist of the NPFF1
= 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
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RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
Rizwan et al.
Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.
Ubuka et al.
PLoS One, 2009;4:e8400
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Hinuma et al.
Nat.Cell Biol., 2000;2:703