RFRP 3 (human)
Biological ActivityAgonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
(Phe-8 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Hinuma et al.
RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
Rizwan et al.
Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.
Ubuka et al.
PLoS One, 2009;4:e8400
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VersaClone cDNA Plasmids
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