Catalog Number: 4683
Alternate Names: Neuropeptide NPVF
Biological Activity
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Phe-8 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
    Rizwan et al.
    Endocrinology, 2012;153:3770
  2. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.
    Ubuka et al.
    PLoS One, 2009;4:e8400
  3. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
    Hinuma et al.
    Nat.Cell Biol., 2000;2:703
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