RFRP 3 (human)

Name: RFRP 3 (human)
Brand: Tocris Bioscience
SKU: 4683

Tocris Bioscience | Catalog # 4683

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Citations (1)

Product Documents

NPFF1 agonist; GnIH homolog

Discontinued Product

4683 has been discontinued. View all Neuropeptide FF/AF Receptor Agonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

NPFF1 agonist; GnIH homolog

Alternative Names

Neuropeptide NPVF

View all Neuropeptide FF/AF Receptor Agonists »

Product Description

RFRP 3 (human) is an agonist of the NPFF₁ receptor (IC₅₀ = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

Product Specifications for RFRP 3 (human)

Molecular Weight

969.15

Formula

C₄₅H₇₂N₁₄O₁₀

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

311309-27-0

PubChem ID

71451611

InChI Key

JFZCLMZUABKABL-GVCDGELBSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Ubuka Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 2009 PMID: 20027225
Hinuma New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2000 PMID: 11025660
Rizwan RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 2012 PMID: 22691552

Product Documents for RFRP 3 (human)

Certificate of Analysis

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Product Specific Notices for RFRP 3 (human)

For research use only

Related Research Areas

Nutrition and Appetite

Obesity

Citations for RFRP 3 (human)

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