Chemical Name: N-Phthalyl-L-tryptophan
Biological ActivityNon-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase.
Brueckner et al.
Cancer Res., 2005;65:6305
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Stresemann et al.
Cancer Res., 2006;66:2794
Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.
Schirrmacher et al.
Citations for RG 108
The citations listed below are publications that use Tocris products. Selected citations for RG 108 include:
3 Citations: Showing 1 - 3
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
Authors: Zhang Et al.
Cell Stem Cell 2016;18:653
Brain feminization requires active repression of masculinization via DNA methylation.
Authors: Nugent Et al.
PLoS One 2015;18:690
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