RG 108

Tocris Bioscience | Catalog # 3295

Non-nucleoside DNA methyltransferase inhibitor
Tocris Bioscience

Key Product Details

Description

Non-nucleoside DNA methyltransferase inhibitor
View all Methyltransferase Inhibitors »

Product Description

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

Product Specifications for RG 108

Molecular Weight

334.33

Formula

C19H14N2O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-Phthalyl-L-tryptophan

CAS Number

48208-26-0

PubChem ID

702558

InChI Key

HPTXLHAHLXOAKV-INIZCTEOSA-N

SMILES

O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.43 100
Ethanol 33.43 100

Preparing Stock Solutions for RG 108

The following data is based on the product molecular weight 334.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.91 mL
5 mM 0.60 mL 2.99 mL 5.98 mL
10 mM 0.30 mL 1.50 mL 2.99 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for RG 108

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RG 108

For research use only

Related Research Areas

Epigenetics

Customer Reviews for RG 108 (2)

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  • Highly stable
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Neural Stem Cells
    Verified Customer | Posted 06/25/2020
    Cells are treated with 10 µM RG 108
    RG 108 3295
  • We got expected effect on cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary pancreatic ductal epithelial cells
    Verified Customer | Posted 04/03/2020
    100 μM RG108
    RG 108 3295

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