Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro
without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase.
Brueckner et al.
Cancer Res., 2005;65:6305
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Stresemann et al.
Cancer Res., 2006;66:2794
Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.
Schirrmacher et al.
The citations listed below are publications that use Tocris products. Selected citations for RG 108 include:
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