RG 108

  ( 2 citations )    
Product Datasheet
Catalog Number:3295
Chemical Name:N-Phthalyl-L-tryptophan
Product Details
Citations (2)
Reviews
Biological Activity
Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
Technical Data
  • M.Wt:
    334.33
  • Formula:
    C19H14N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    48208-26-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for RG 108 include:

2 Citations: Showing 1 - 2
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  1. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell  2016;18:653
  2. Brain feminization requires active repression of masculinization via DNA methylation.
    Authors: Nugent Et al.
    PLoS One  2015;18:690

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