Biological ActivityIntegrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.
Grigoriou et al.
Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways.
Moon et al.
Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin.
Droppelmann et al.
Citations for RGDS peptide
The citations listed below are publications that use Tocris products. Selected citations for RGDS peptide include:
7 Citations: Showing 1 - 7
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis.
Authors: Bian Et al.
Bone Res 2017;5:17008
Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.
J Neuroinflammation 2017;14(1):56
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells.
Authors: Ahmed Et al.
J Radiat Res 2015;2:85
Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
Authors: Kang Et al.
J Neurosci 2012;32:9277
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Co-incubated with RGDS 10 µg/ml