Catalog Number: 3498
Biological Activity
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.
    Grigoriou et al.
    J.Biol.Chem., 2005;280:1733
  2. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways.
    Moon et al.
    Respir.Res., 2009;10:18
  3. Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin.
    Droppelmann et al.
    J.Biol.Chem., 2009;284:13551

The citations listed below are publications that use Tocris products. Selected citations for RGDS peptide include:

Showing Results 1 - 2 of 2

  1. Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells.
    Authors: Ahmed Et al.
    J Radiat Res
  2. Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
    Authors: Kang Et al.
    J Neurosci
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