Catalog Number: 3498
Biological Activity
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
Technical Data
  • M.Wt:
    433.42
  • Formula:
    C15H27N7O8
  • Sequence:
    RGDS
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    91037-65-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.
    Grigoriou et al.
    J.Biol.Chem., 2005;280:1733
  2. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways.
    Moon et al.
    Respir.Res., 2009;10:18
  3. Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin.
    Droppelmann et al.
    J.Biol.Chem., 2009;284:13551
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RGDS peptide include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.
    Authors: Conant
    J Neuroinflammation 2017;14(1):56
  2. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling 2016;14:32
  3. Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells.
    Authors: Ahmed Et al.
    J Radiat Res 2015;2:85
  4. Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
    Authors: Kang Et al.
    J Neurosci 2012;32:9277

Have you used RGDS peptide?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information