Inhibitor of diacylglycerol lipase (IC50
values are 1.1 and 4 μ
M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2
. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50
= 4 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action.
Ghisdal et al.
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase.
Sutherland and Amin
Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum.
Suzuki et al.
J.Smooth Muscle Res., 2002;38:153
The citations listed below are publications that use Tocris products. Selected citations for RHC 80267 include:
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