Catalog Number: 1842
Alternate Names: U 57908
Chemical Name: O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone
Biological Activity
Inhibitor of diacylglycerol lipase (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM).
Technical Data
  • M.Wt:
    394.51
  • Formula:
    C20H34N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >95%
  • Storage:
    Store at +4°C
  • CAS No:
    83654-05-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action.
    Ghisdal et al.
    Eur.J.Pharmacol., 2005;517:97
  2. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase.
    Sutherland and Amin
    J.Biol.Chem., 1982;257:14006
  3. Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum.
    Suzuki et al.
    J.Smooth Muscle Res., 2002;38:153
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RHC 80267 include:

4 Citations: Showing 1 - 4
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  1. Perilipin 1 moves between the fat droplet and the endoplasmic reticulum.
    Authors: Skinner Et al.
    Adipocyte 2013;2:80
  2. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem 2011;18:545
  3. The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.
    Authors: Breunig Et al.
    Am J Physiol Gastrointest Liver Physiol 2010;30:8965
  4. Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization.
    Authors: Skinner Et al.
    J Biol Chem 2009;284:30941

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