Catalog Number: 4440
Alternate Names: ENA 713
Chemical Name: N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate
Biological Activity
Dual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant.
Technical Data
  • M.Wt:
    400.42
  • Formula:
    C14H22N2O2.C4H6O6
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    129101-54-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.
    Groner et al.
    Mol.Pharmacol., 2007;71:1610
  2. Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
    Luo et al.
    J.Med.Chem., 2006;49:2174
  3. New acetylcholinesterase inhibitors for Alzheimer's disease.
    Mehta et al.
    Int.J.Alzheimers Dis., 2012;:Epub 2011
  4. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons.
    Bailey et al.
    PLoS One, 2011;6:e21954
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rivastigmine tartrate include:

1 Citations: Showing 1 - 1

  1. Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice.
    Authors: Budzynska Et al.
    Curr Alzheimer Res 2015;232:931

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