Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50
= 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50
values are 0.51 and 2.79 μ
M for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.
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Brain-penetrant LSD1 inhibitors can block memory consolidation.
Neelamegam et al.
ACS Chem.Neurosci., 2012;3:120