RN 1 dihydrochloride

Catalog # Availability Size / Price Qty
4977/10
4977/50
RN 1 dihydrochloride | CAS No. 1781835-13-9 | Histone Demethylase Inhibitors
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Description: LSD1 inhibitor

Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Technical Data

M.Wt:
452.42
Formula:
C23H29N3O2.2HCl
Solubility:
Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1781835-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Brain-penetrant LSD1 inhibitors can block memory consolidation.
    Neelamegam et al.
    ACS Chem.Neurosci., 2012;3:120

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Citation for RN 1 dihydrochloride

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