RN 1 dihydrochloride
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Biological ActivityRN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Brain-penetrant LSD1 inhibitors can block memory consolidation.
Neelamegam et al.
ACS Chem.Neurosci., 2012;3:120
Citation for RN 1 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RN 1 dihydrochloride include:
1 Citation: Showing 1 - 1
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Authors: Llewellyn Et al.
J Neurovirol 2018;24:192
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