Catalog Number: 4977
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Biological Activity
Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.
Technical Data
  • M.Wt:
    452.42
  • Formula:
    C23H29N3O2.2HCl
  • Solubility:
    Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    1781835-13-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Brain-penetrant LSD1 inhibitors can block memory consolidation.
    Neelamegam et al.
    ACS Chem.Neurosci., 2012;3:120

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