Selective TRPV4 antagonist (IC50
values are 2.3, 3.2 and 5.9 μ
M for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50
values are 2.3, >30, >30 and >100 μ
M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification and characterization of novel TRPV4 modulators.
Vincent et al.
Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.
Bagher et al.
The citations listed below are publications that use Tocris products. Selected citations for RN 1734 include:
Showing Results 1 - 5 of 5