Catalog Number: 2272
Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Biological Activity
Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NGF ligand alters NGF signaling via p75NTR and TrkA.
    Niederhauser et al.
    J.Neurosci.Res., 2000;61:263
  2. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
    Arkin and Wells
    Nat.Rev.Drug Discov., 2004;3:301
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