Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Biological ActivityNon-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
NTRK1 is a positive regulator of YAP oncogenic function.
Yang et al.
NGF ligand alters NGF signaling via p75NTR and TrkA.
Niederhauser et al.
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
Arkin and Wells
Nat.Rev.Drug Discov., 2004;3:301
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