Non-peptide inhibitor of NGF that binds the NGF dimer (KD
~ 1 μ
M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR
at submicromolar concentrations, and to both p75NTR
and TrkA at concentrations > 5 μ
M. Prevents NGF-induced apoptosis in SK-N-MC cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NGF ligand alters NGF signaling via p75NTR and TrkA.
Niederhauser et al.
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
Arkin and Wells
Nat.Rev.Drug Discov., 2004;3:301